Local Glymphatic Dysfunction in Multiple System Atrophy: Insights from Multimodal MRI
Objective: To evaluate multimodal glymphatic-related MRI proxies in multiple system atrophy (MSA) and explore their relationship with clinical features. Background: Impaired fluid transport and waste…Distinct FDG-PET metabolic patterns and connectivity alterations in dopamine transporter-deficient versus -preserved MSA-C
Objective: In this study, we stratified MSA-C patients by DaT-PET binding status (preserved vs deficient) and compared their 18F-FDG PET metabolic patterns and inter-regional metabolic…Clinicogenetic Characterization of Sporadic Adult-Onset Ataxias in Austria
Objective: To gain insight in the natural history of sporadic adult-onset ataxia (SAOA), identify unrecognized genetic underpinnings and improve early differentiation from other causes of…Micrographia in Parkinson’s Disease and Multiple System Atrophy: A Quantitative Tablet-Based Handwriting Study
Objective: To evaluate the relative contributions of cognitive and motor factors to handwriting performance in patients with MSA and PD using quantitative tablet-based tasks. Background:…Differential Cholinergic White Matter Microstructural Alterations in Multiple System Atrophy and Parkinson’s Disease
Objective: To investigate the extent and pattern of microstructural alterations of cholinergic pathways in MSA and PD. Background: MSA and PD are both α-synucleinopathies with…Exploring Swallowing Dysfunction, Quality of Life, and Caregiver Burden in Multiple System Atrophy
Objective: To investigate associations between swallowing-related symptoms and disease severity, quality of life, and caregiver burden in patients with MSA in a large UK-based cohort.…Clinical Correlates of Dysphagia in Multiple System Atrophy: A Multicenter Retrospective Study
Objective: To identify clinical factors associated with dysphagia severity in patients with MSA. Background: Dysphagia is a common and clinically important complication in multiple system…Towards Biomarker-Driven Staging of Multiple System Atrophy Using Longitudinal Neurofilament Light Profiling
Objective: To evaluate neurofilament light chain (NfL) as a longitudinal biomarker of disease burden and progression in Multiple System Atrophy and to explore its potential role…Prognostic Factors for Survival in Multiple System Atrophy: A Retrospective Cohort Study with Focus on Surgical Interventions
Objective: To investigate prognostic factors associated with survival in patients with multiple system atrophy (MSA), with particular focus on surgical interventions. Background: MSA is a…Pathology Meets Clinical Practice: Unveiling the Pathological Evidence of Clinical Signs in Multiple System Atrophy
Objective: This study aimed to evaluate the pathological evidence of the core and supportive clinical features of multiple system atrophy (MSA) based on The Movement…
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