Automated Differentiation for Early Parkinsonism Using Clinical Structural MRI: A Multicenter Study
Objective: To develop and validate a T1-weighted structural MRI–based machine learning model for differentiating Parkinsonism at early-to-mid stage and generalize the model to routine anisotropic…Beyond Diagnosis: Putaminal ADC Hyperintensity and Infratentorial Signs Reflect Motor Severity in MSA
Objective: To clarify the clinical significance of neuroimaging markers in multiple system atrophy (MSA) by (1) examining concordance among putaminal MRI markers across sequences, (2)…Does CANVAS mimic MSA-C
Objective: To describe the natural history of RFC1-related ataxia, identify discriminative features compared to MSA-C, and study their survival outcomes. Background: AAGGG intronic expansions in…Proteome-Wide Association and Mendelian Randomization Analyses Identify Plasma GUSB as a Potential Biomarker for Multiple System Atrophy
Objective: To identify plasma protein biomarkers associated with MSA and investigate their potential causal relationships using integrative proteomic and genetic approaches. Background: Multiple System Atrophy…Evaluation of Semantic Space Search Metrics in Phonemic Fluency: Comparison among Basal Ganglia Disorders and Healthy Controls
Objective: Phonemic verbal fluency reflects executive function and involves both within-category lexical retrieval (cluster size) and switching between categories. We compared semantic search behavior in…Task-Dependent Modulation of Reflexive and Voluntary Saccades in Parkinson Disease and Multiple System Atrophy
Objective: The present study aimed to quantitatively compare reflexive and voluntary saccades in patients with Parkinson’s disease (PD) and multiple system atrophy (MSA), and to…Multiple System Atrophy Without Dysautonomia
Objective: TTo investigate the frequency, clinical characteristics, and disease trajectory of patients with MSA presenting without dysautonomia and to compare their course with patients showing…Ultra-early Diagnosis of MSA-C Using Biological Biomarkers: A Two-Case Study Employing α-Synuclein PET and Fluid α-Synuclein Seeds Amplification Assay (SAA)
Objective: To report cases in which combined α-synuclein PET and body fluid α-synuclein seeds amplification assay (SAA) enabled biological diagnosis of multiple system atrophy–cerebellar type…Novel Structural MRI-Based Progression Subtypes and Prognostic Study in Multiple System Atrophy
Objective: To identify structural MRI-based progression subtypes in multiple system atrophy (MSA) and determine whether these imaging-defined subtypes are associated with distinct clinical features, molecular…Diagnostic Delay in Multiple System Atrophy: Sociodemographic and Clinical Predictors in a Single-Center Cohort
Objective: To evaluate sociodemographic and clinical predictors of diagnostic delay in multiple system atrophy (MSA) at a single tertiary referral center. Background: MSA is a…
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