Plasma Protein Profiles Reveal Distinct Molecular Signatures in Parkinson’s Disease and Multiple System Atrophy
Objective: We aimed to identify distinct plasma proteins in patients with Parkinson’s disease (PD) and multiple system atrophy (MSA) and evaluate their associations with disease…Distinct Peripheral Immune Profiles of Parkinson’s Disease and Multiple System Atrophy
Objective: We aimed to compare peripheral blood mononuclear cell (PBMC) subsets between Parkinson’s disease (PD) and multiple system atrophy (MSA) to identify disease-specific immune signatures…Differential Effect of alpha-Synuclein on Mitochondrial Morphology in PD and MSA
Objective: In this study, we investigated the morphology of mitochondria and localization of alpha-synuclein as driven by alpha-synuclein isolated from PD and MSA brain-derived tissue.…Efficacy and Feasibility of Telemedicine-Based Dietary Intervention vs. Outpatient Supervision for Drug-Resistant Multiple System Atrophy in Postmenopausal Women During COVID-19
Objective: This study aimed to evaluate the feasibility, safety, and patient satisfaction of initiating and following up on MAD via telemedicine using the Telegram app,…Rethinking Parkinsonism: Limitations in Clinical Diagnosis
Objective: To highlight the limitations in clinically differentiating PD and MSA. Background: The antemortem differentiation of parkinsonian syndromes remains challenging due to overlapping symptomatology, particularly…MicroRNA Landscape of Multiple System Atrophy: Insights from Plasma and Patient-Derived Induced Pluripotent Stem Cell Models
Objective: To identify small non-coding RNAs (sncRNAs) signatures in multiple system atrophy (MSA) and elucidate their functional mechanisms within patient-derived induced pluripotent stem cell-differentiated oligodendrocytes…Proteome-Wide Association Study Identifies Plasma β-Glucuronidase as a Causal Risk Protein for Multiple System Atrophy
Objective: This study aims to identify plasma proteins associated with multiple system atrophy (MSA), using a proteome-wide association study (PWAS) and to determine their causal roles…Atrophy In Multiple System Atrophy Relates To Mitochondrial And Oligodendrocytic Processes
Objective: To investigate the gene expression and neurobiological underpinnings of brain atrophy in MSA using imaging transcriptomics and PET-based molecular annotation Background: The biological mechanisms…Plasma MicroRNA Expression Profiling in patients with Multiple System Atrophy and Parkinson’s Disease
Objective: Our objective was to identify differentially expressed, circulating miRNAs in Multiple System Atrophy-Parkinsonian type (MSA-P) and Parkinson’s disease (PD) which could serve as diagnostic…Altered activity of lysosomal hydrolases in monocyte-derived macrophages as potential biomarker for differential diagnosis of multiple system atrophy
Objective: The aim was to assess the possibility of differentiating synucleinopathies (Parkinson’s disease (PD), dementia with Lewy bodies (DLB), multiple system atrophy (MSA) by lysosomal…
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