VMAT2 OVEREXPRESSION REDUCES INTRACELLULAR NEUROMELANIN LEVELS AND ATTENUATES PARKINSON-LIKE PATHOLOGY IN NEUROMELANIN-PRODUCING PARKINSONIAN RATS
Objective: Because neuromelanin derives from the oxidation of free cytosolic dopamine, we hypothesized that enhancing dopamine vesicular encapsulation with vesicular monoamine transporter 2 (VMAT2) will…Age-dependent multisystem parkinsonian features in a novel neuromelanin-producing transgenic mouse model
Objective: We aim to characterize the consequences of age-dependent intracellular neuromelanin accumulation in catecholaminergic neuronal populations to understand the relationship between this process and the…Longitudinal changes in nigral neuromelanin in early, levodopa-treated Parkinson’s disease
Objective: To assess longitudinal changes in neuromelanin (NM) content in the substantia nigra compacta (SNc) and its lateral-ventral subregion in Parkinson’s disease (PD). Background: NM-sensitive…Does neurodegeneration of the noradrenergic locus coeruleus follow a spatial gradient in Parkinson’s disease?
Objective: To map degeneration of the locus coeruleus in Parkinson’s disease in-vivo using ultra-high field MRI. Background: Parkinson’s disease (PD) causes degeneration of dopaminergic neurons…L-DOPA treatment in N2a cells stimulates neuromelanin biosynthesis: Using a novel in vitro model to examine the effect of iron and light on neuromelanin production
Objective: Naturally-occuring quantities of in vivo neuromelanin (NM) are low, and the collection of NM from tissue involves laborious extraction and isolation. Thus, in vitro…Neuromelanin MRI detects monoaminergic cell loss in Huntington Disease Expansion Gene Carriers.
Objective: To measure, with NM-MRI, the integrity of neuromelanin-containing monoaminergic cells in the SN and LC in Huntington Disease Gene Expansion Carriers (HDGECs) and compare…Sequencing of single human nigral dopaminergic neurons for somatic copy number variants
Objective: To detect somatic DNA copy number variants (CNVs) in dopaminergic neurons isolated from human substantia nigra, using shallow whole genome sequencing (WGS). Background: Somatic…Neuromelamin-MRI in patients with Pure Autonomic Failure
Objective: To assess the utility of neuromelanin-MRI (NM-MRI) methods in a prodromal alpha-synuclein disorder, Pure Autonomic Failure (PAF). Background: PAF is a peripheral alpha-synucleinopathy (AS)…Depressive Symptoms are Associated with Lower Locus Coeruleus Volumes in Parkinson’s disease
Objective: To assess locus coeruleus volumes in Parkinson's disease patients with depressive symptoms. Background: Depression associated with Parkinson disease (PD) has a different symptom profile…Imaging biomarker for progression of motor symptoms in advanced Parkinson’s disease
Objective: The aim of the present study is to clarify correlation between motor deficits and dopaminergic neuronal loss in advanced Parkinson’s disease (PD). Background: Series…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.