Localization and functional study of synaptic vesicle protein synaptogyrin-3 (SYNGR3) on dopaminergic neuronal system
Objective: To investigate (1) the intracellular localization of SYNGR3 and its interaction with dopamine transporter (DAT); (2) how expression of SYNGR3 in neurons affects dopamine…Automatic event-detection for the neurophysiological evaluation of voluntary and involuntary movements
Objective: This project aims at creating a tool for automatic EMG event- detection to support clinicians in this process. Background: Neurophysiological evaluation of voluntary and…AMP kinase regulates ligand-gated K-ATP channels in substantia nigra dopamine neurons
Objective: To characterize the effect of AMP-activated protein kinase (AMPK) on ATP-sensitive K+ (K-ATP) channels on substantia nigra compacta (SNC) dopamine neurons in slices of…A whole brain anatomical network model and its application in PD research
Objective: To build a frame of whole brain anatomical network for incorporating different data from different studies with different brain parcellations and resolutions, to evaluate…Nigrostriatal degeneration and serum BDNF levels in patients with “de novo” untreated Parkinson’s disease
Objective: To evaluate serum Brain-Derived NeurotrophicFactor(BDNF) levels in “de novo” untreated Parkinson's disease (PD) patients and their relationship to nigrostriatal degeneration measured with [123I]FP-CIT SPECT.…Proprioceptive training as a means to enhance sensorimotor function in Parkinson’s disease
Objective: To identify whether proprioceptive function in Parkinson's disease (PD) can be enhanced by specialized visuomotor training that emphasizes precise movements and determine if such…Parkinson’s disease motor subtypes show similar deficits in inhibitory control
Objective: To determine whether predominant motor subtypes of Parkinson's disease (PD) differentially impact distinct forms of inhibitory motor control. Background: Parkinson's disease (PD) impairs rapid…Levodopa induced dyskinesia and nicotinergic α4β2 acetylcholin receptor density: A multi-tracer imaging study
Objective: We investigated α4β2 acetylcholin receptor (nAChR) density in subjects with Parkinson's disease (PD) with and without levodopa-induced dyskinesia (LID) and its correlation with dopaminergic…
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