Safety, Tolerability, and Pharmacodynamic Profile of DNL201 at dose levels demonstrating LRRK2 inhibition in Parkinson’s Disease Patients with and without LRRK2 mutations
Objective: To evaluate safety, tolerability, and target engagement of DNL201, a LRRK2 inhibitor, in Parkinson’s disease (PD) patients. Background: Mutations in LRRK2 impact both familial…Rapid on-time onset and sustained improvements in motor states throughout the day following treatment with levodopa/carbidopa intestinal gel (LCIG) vs immediate-release levodopa/carbidopa oral capsules (LCIR)
Objective: To assess the speed of on-time onset and characterize the patterns of motor states throughout the day in advanced Parkinson’s disease patients treated with…A Discrete-Choice Experiment Evaluating Preferences for On-Demand Treatments for Patients with Parkinson’s Disease and “OFF” Episodes
Objective: To quantify patient preferences for on-demand treatments among patients with Parkinson’s disease (PD) and “OFF” episodes. Background: Patients with PD develop potentially disabling “OFF”…Euphoria-inducing lead contacts: mapping of image and electrophysiology in Parkinson’s disease
Objective: We characterized stimulation-induced euphoria during the programming of STN DBS. The lead contacts where euphoria was elicited were characterized anatomically and electrophysiologically. Background: Mood…Opicapone and entacapone as add-on therapy to the treatment of infusions of levodopa-carbidopa intestinal gel in patients with advanced Parkinson’s disease
Objective: To study the effect of COMT inhibitors (opicapone and entacapone) in Parkinson's disease (PD) patients on levodopa-carbidopa intestinal gel (LCIG) and an insufficient control of…Automated classification of neurodegenerative parkinsonian syndromes using multimodal magnetic resonance imaging in a clinical setting
Objective: To evaluate the accuracy for the categorization of parkinsonian syndromes of a machine learning algorithm trained with a research cohort and tested on an…Patient Characteristics, Treatment Patterns and Disease Burden in People with Parkinson’s Disease: Insights from the Parkinson’s Disease Real-World Impact Assessment (PRISM) Study
Objective: Data from the PRISM study on patient characteristics, treatment patterns and burden of disease in people with Parkinson’s disease (PwP) are presented. Background: PRISM…Objective Measurement of Muscle Mechanical Properties using a Myometric Device in People with Parkinson’s Disease in a Clinical Setting in Africa
Objective: To examine the feasibility and reliability of using a myometric device to objectively measure mechanical properties of muscles in people with Parkinson’s disease in…Network-Based Healthcare at Kaiser Permanente
Objective: To present the initial outcomes following adoption of the Dutch ParkinsonNet model at Kaiser Permanente Southern California (KPSC). Background: Parkinson’s disease (PD) is a…Resource patients involved in a program of therapeutic education of patients with Parkinson’s disease: contribution to patients’ recruitment
Objective: Evaluate the quantitative and qualitative contributions of ‘resource-patients’ (RP) to a Therapeutic Patient Education program (TPE) in Parkinson's disease (PD). Background: TPE is a…
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