Investigation of the incidences of non-motor symptoms in first-degree relatives and the spouses of patients with Parkinson’s disease
Objective: The first-degree relatives of PD patients (such as siblings) and the spouses living together for many years do not have classic motor symptoms. However,…A Study of Pain in Parkinson’s Disease
Objective: To study the prevalence, type and severity of pain in patients with Parkinson’s disease. Background: Pain is one of the recognised non-motor symptoms in…Experimental rotenone model
Objective: To evaluat rotene model of parkinsonian syndrome in rats. Background: Rotenone is of highly lipophilic substances that can freely enter hematoencephalic barrier through and…Properties of oscillatory neuronal activity in the basal ganglia and thalamus in patients with Parkinson’s disease
Objective: To characterize the firing rate and pattern of oscillatory neurons in basal ganglia and thalamus in patients with Parkinson’s disease (PD). Background: The cardinal…The Prevalence of Tandem Gait Abnormality in Parkinson’s Disease
Objective: To assess the prevalence of tandem gait abnormality in patients with Parkinson’s disease (PD), comparing Hoehn and Yahr (HY) stages 2 and 3. Background:…Intercultural differences in the frequency of impulsive control disorders in Parkinson’s disease
Objective: To study if there were intercultural differences in the prevalence of these impulse control disorders in PD. Background: Impulse control disorders (ICD) era common…INTREPID: A Prospective, Double Blinded, Multicenter Randomized Controlled Trial Evaluating Deep Brain Stimulation with a New Multiple Source, Constant Current Rechargeable System in Parkinson’s disease
Objective: INTREPID is designed to assess the improvement in motor function and quality of life in patients with Parkinson’s disease (PD) following Deep Brain Stimulation…Intraoperative local field potential recordings from deep brain stimulation electrodes help predict efficacy of subthalamic nucleus stimulation in patients with Parkinson’s disease
Objective: Subthalamic nucleus (STN) deep brain stimulation(DBS) is an effective treatment for advanced Parkinson's disease (PD). Two electrophysiological techniques aid identification of the optimal target.…Dissecting molecular signatures of X-linked dystonia-parkinsonism (XDP) through integrative genomics studies
Objective: To determine the causal locus and functional mechanism associated with XDP using integrative genomics methods in patient-derived and genome-edited induced pluripotent stem cell (iPSC)…Novel biomarkers of autonomic regulation and sleep in Parkinson’s Disease derived from Network Physiology
Objective: Utilize a novel Network Physiology approach to identify new biomarkers of Parkinson’s Disease (PD) based on the dynamics on individual physiological systems, and their…
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