Resting-state network reorganization following multimodal lifestyle intervention in Parkinson’s disease
Objective: To investigate longitudinal changes in resting-state (rs) functional connectivity following a multimodal lifestyle intervention in individuals with Parkinson's disease (PD). Background: PD is associated with disruption of large-scale…Phenotypic and Genotypic Spectrum of MAPT-associated Parkinsonism in a Multi-ethnic Malaysian Cohort
Objective: To describe the phenotypic continuum and genotypic spectrum of microtubule-associated protein tau (MAPT)-associated parkinsonism in a multi-ethnic Malaysian cohort. Background: Carriers of pathogenic MAPT…Variants in Cytochrome P450–encoding Genes Associated with Parkinson’s Disease
Objective: To characterize the clinical features of PD associated with CYP gene variants (CYP‑iPD) and parkinsonism observed in other neurodegenerative diseases. Background: Cytochrome P450 (CYP)…The Lived Experience of Parkinson’s Disease in the Philippines: Challenges, Cultural Constructs, and Caregiving Impacts
Objective: This study aims to explore the lived experiences of PD patients and their caregivers in Cebu Province, Philippines; identify psychosocial and healthcare-related challenges; assess…Neurofilament Light Chain as a Prognostic Marker of Motor Progression in Parkinson’s Disease: A Systematic Review
Objective: To identify systematically studies evaluating CSF, serum, and plasma NfL as a prognostic factor for clinical progression in PD and to describe study characteristics…Multi-Ancestry Analysis of Repeat Expansions in Parkinson’s Disease
Objective: To systematically assess known disease-causing repeat expansions detectable by short-read sequencing in Parkinson’s Disease (PD) and atypical parkinsonism and examine repeat length-disease relationships to…Clinical outcomes of deep brain stimulation for Parkinson’s disease in the Dominican Republic: results from a newly established single-center DBS program
Objective: To evaluate motor improvement after bilateral STN-DBS in patients with Parkinson’s disease in the Dominican Republic. Secondary objectives included assessing reduction in dopaminergic medication…Dopaminergic Medication Changes Following LFP-Guided Deep Brain Stimulation Programming in Parkinson’s Disease: A Single-Centre Audit
Objective: To evaluate changes in levodopa equivalent daily dose (LEDD) following deep brain stimulation (DBS) with local field potential (LFP)-guided programming in patients with Parkinson’s disease.…Wearable IMU-Based Gait Analysis Reveals Pharmacological Freezing-of-Gait Phenotypes in Parkinson Disease: A Longitudinal Two-Visit Study
Objective: TolongitudinallyevaluatewearableIMU-derived gaitparameters across two clinical visits andcharacterizepharmacological responsephenotypes inParkinsondiseasepatientswith freezingof gait (FOG). Background: FOG affects upto 80% of patientswith advanced PD and frequentlydemonstrates absent…Designing a virtual reality-based rehabilitation therapy for Parkinson disease
Objective: The study aims to determine design considerations for a virtual reality-based therapy targeting motor disabilities of Parkinson disease (PD) patients. Background: PD has the…
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