Expanding Diversity of Parkinson’s Disease and Related Disorders Genetic Data: from the Global Parkinson’s Genetics Program
Objective: To expand the research dataset for Parkinson’s Disease (PD) and related disorders by including >50,000 participants globally who have been genotyped or whole genome…LRRK2 Gene Mutation in Parkinson’s Disease
Objective: We aim to describe the clinical characteristics of PD linked to an LRRK2 mutation. Background: One of the most common monogenic forms of Parkinson's…Correlation of Neural Sensing with the Volume of Neural Activation within the Desired Patient-Specific Anatomical Target in Deep Brain Stimulation for Parkinson’s Disease
Objective: Investigate the correlation between power in local field potential (LFP) beta band sensed from the subthalamic nucleus (STN) and the volume of neural activation…Exploring the Therapeutic Potential of Microglial Modulation in Parkinson’s Disease: A Study on Structural Synaptic Plasticity
Objective: We aim to explore the role of glial cells in Parkinson's disease and assess whether modulating microgliafunction could offer therapeutic benefits. Specifically, we investigate…A pathology-validated study to investigate the role of Uric Acid in Parkinson’s Disease
Objective: The aim of this study is to compare plasma uric acid levels between pathology-confirmed and clinically misdiagnosed Parkinson’s disease patients at a single-patient level.…Burden of Movements Disorders at Initiative Plus Center Hospital
Objective: describe the socio-demographic, clinical characteristics and evolutionary profiles of patients followed for movement disorders Background: The DR Congo specialists in abnormal movements are rare,…Improving awareness of motor fluctuations in Parkinson’s Disease: an educational patient support program using a waist-worn device.
Objective: To describe the utility of an educational patient support program designed to improve awareness of motor fluctuations (MF) and provide education on motor and…Utility of Serum α-synuclein Seed Amplification Assay as a Parkinson’s Disease Biomarker
Objective: To determine the sensitivity and specificity of serum α-synuclein seed amplification assay (SAA) for Parkinson’s disease (PD) diagnosis in the Systemic Synuclein Sampling Study…Bedside Assessment of Downgaze Palsy by Amplitude in Patients with Progressive Supranuclear Palsy
Objective: To assess the specificity and reliability of the bedside assessment of downgaze palsy by amplitude based on the upper edge of the iris relative to…Impact of Temperature Variation on Emergency Department Visits for Parkinson’s Disease Patients Amongst Two Sites
Objective: We aim to examine the impact of ambient temperature fluctuations on Parkinson’s disease (PD) patients across two distinct climates. Background: PD is a neurodegenerative…
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