Levodopa-induced orthostatic hypotension in a large cohort of patients with Parkinson’s disease undergoing an acute levodopa challenge test
Objective: We aimed to investigate the frequency and associated risk factors for Levodopa-induced orthostatic hypotension (OH) in a large cohort of PD patients underwent acute…Rasagiline in Chinese patients with early-stage parkinson’s disease: a randomized, double-blind, placebo-controlled, delayed-start trial
Objective: Objective: This randomized, double-blind, placebo-controlled, delayed-start trial aimed to investigate the efficacy in symptom improvement and disease-modifying effect of rasagiline for Chinese patients with…Diplopia (Double vision) in Parkinson’s disease patients: prevalence and nonmotor effect
Objective: To assess the prevalence of diplopia in Parkinson’s disease (PD) patients and the correlation of diplopia with visual hallucinations, cognitive dysfunction and motor performance.…Fluorescence-lifetime ophthalmoscopy findings in Parkinson’s disease patients with visual disturbances
Objective: We identified fluorescence-lifetime ophthalmoscopy changes in Parkinson’s disease (PD) patients experiencing visual disturbances. Background: Fluorescence-lifetime ophthalmoscopy (FLIO), a novel in vivo imaging method generating…Targeting autophagy to identify novel modulators of Parkinson’s disease using midbrain organoids
Objective: Natural compound libraries are a great source of new chemical molecules that could restore the altered phenotypes in patient derived cells. The objective of…Gray matter volume changes in occipital and temporal visual brain region are associated with freezing of gait in Parkinson’s
Objective: This study aimed to investigate the association of changed gray matter volume(GMV)with Freezing of gait(FOG) in Parkinson’s disease(PD). Background: FOG is a characteristic gait…Epigenome-wide meta-analysis of sex-differential DNA methylation in Parkinson’s disease
Objective: To comprehensively characterize the blood-based DNA methylation alterations related to sex in patients with Parkinson's disease (PD), shedding light on the underlying genes and…Connectomic DBS informed multifocal transcranial direct current stimulation (tDCS) in Parkinson’s Disease: a crossover double blinded study
Objective: To determine if non-invasive neuromodulation of a network previously identified through invasive neuromodulation could improve motor symptoms in Parkinson's disease (PD). Background: A recent…Motor complications in Parkinson’s disease
Objective: To determine the presence, severity, functional impact and predisposing factors of motor complications. Background: Motor complications are well recognized in Parkinson’s disease (PD), but…Design of a Phase 2 Study of Suvecaltamide in Moderate to Severe Parkinson’s Disease Tremor
Objective: Describe the design of a phase 2 study (NCT05642442) of a once-daily, extended-release formulation of suvecaltamide to treat moderate to severe Parkinson’s disease tremor…
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