London-Dhaka Parkinson’s Cognition Study: A collaboration to evaluate cognitive impairment in under-represented Parkinson’s disease patients
Objective: Our aim is to study the prevalence of cognitive impairment (CI) in a diverse group of people with Parkinson's disease (PwP) from East London,…motor and non-motor correlates of hyposmia detected by the italian olfactory identification test (ioit) in an italian cohort of parkinson’s disease patients
Objective: To characterize olfaction in a cohort of PD patients and to investigate the relationship between olfactory impairment with both motor and non-motor features and other clinical characteristics…MR-morphological changes in PD patients with heterozygous GBA mutation
Objective: This study investigates possible cerebral morphological differences between GBA-gene-mutation carriers with Parkinson´s disease (PD) and PD-patients without GBA-gene-mutation depending on in- or exclusion of…Parkinson’s disease and Charcot-Marie-Tooth type 2: coincidental or causal?
Objective: To report a patient with Charcot-Marie-Tooth (CMT) type 2N (CMT2N) due to AARS gene mutation who developed early-onset Parkinson’s disease (PD). Background: Aminoacyl tRNA…Optimal topographic characteristics of focused ultrasound unilateral thalamotomy for tremor-dominant Parkinson´s disease
Objective: To define topography that correlates with tremor control after unilateral focused ultrasound (FUS) thalamotomy for tremor-dominant Parkinson´s Disease (TDPD). Background: Unilateral FUS thalamotomy of…Parkinson’s disease management in the community
Objective: To explore perceptions of people with Parkinson's disease and family carers about the use and impact of health and social care services, community and…Exome-wide contribution of ultra-rare variants to the genetic architecture of Parkinson’s disease and Cutaneous Malignant Melanoma
Objective: To analyze the UKBiobank cohorts of Parkinson’s disease (PD) and Cutaneous Malignant Melanoma to uncover shared genetic factors explained by ultra-rare damaging coding variants…A pilot, randomized, placebo controlled, double-blinded, delayed start trial of Modafinil for the treatment of Freezing of Gait in Parkinson’s disease.
Objective: To determine if modafinil could improve gait and freezing in people with Parkinson’s disease (PwPD)with freezing of gait (FOG). Background: FOG is a debilitating…Application of multi-parametric diffusion MRI in detecting visual disturbances in advanced Parkinson’s disease population
Objective: We aimed to identify differences in multi-parametric diffusion indices (DTI, NODDI, and DKI) between Parkinson’s disease patients with visual disturbances and those without. Background:…Longitudinal clinical and biomarker characteristics of non-manifest GBA1 N409S carriers: the PPMI cohort
Objective: To examine longitudinal change in clinical characteristics, dopamine transporter (DAT) imaging and biofluid biomarkers in GBA1 N409S non-manifesting carriers (NMCs) versus healthy controls (HCs)…
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