Determinants of Quality of Life According to Brain-first and Body-first in Patients with Parkinson’s Disease
Objective: In this study, we aimed to investigate the potential determinants of QoL in brain-first and body-first patients with PD. Background: Parkinson’s disease (PD) is…Integrating Transcriptomics and Morphological Profiling to Characterize GBA-Associated Parkinson’s Disease in Midbrain Organoids
Objective: This study characterizes converging biological trends in GBA-associated Parkinson’s Disease by integrating transcriptomic profiling with exploratory image-based analysis of donor-matched midbrain organoids. Background: High-content…Sleep Disorders and Risk of Parkinson’s Disease: A Systematic Review and Meta-Analysis
Objective: To comprehensively evaluate the association between various sleep disorders and the risk of developing Parkinson’s disease. Background: Sleep disturbances are increasingly recognized as important…Real-Time Quaking-Induced Conversion Detection of Tear Fluid α-Synuclein as a Potential Biomarker for Parkinson’s Disease
Objective: To detect α-synuclein (aSyn) in tear fluid and to evaluate the clinical characteristics of aSyn-positive patients. Background: Parkinson's disease (PD) is an α-synucleinopathy. Pathological…Neurotwain: Extended-reality based virtual brain imaging for one-stop-shop diagnosis and progression of Parkinson’s Disease
Objective: We propose a new non-invasive, wearable, ambulatory, and cost-effective virtual imaging platform, Neurotwain, to screen individuals and obtain a baseline test to evaluate risk…Optimizing Institutional Long-Term Care in Advanced Parkinson’s and Other Neurodegenerative Disease: The OPTICARE Study
Objective: To analyze and improve institutional long-term care (LTC) structures for patients with advanced PD and AD by identifying modifiable determinants of care integration, QoL,…Cardiac Pacing Strategies for Cardiovascular Autonomic Dysfunction in Parkinson’s Disease
Objective: To present three illustrative cases of PD-associated autonomic dysregulation with severe orthostatic symptoms in which cardiac pacing strategies were associated with substantial clinical improvement.…Baseline plasma neurofilament light and phosphorylated tau 181 levels predict longitudinal cognitive decline in APOE4 and long SNCA Rep1 carriers in Parkinson’s disease
Objective: Plasma neurofilament light (NfL; a marker of axonal injury) and phosphorylated tau 181 (pTau181) are biomarkers that have been associated with cognitive decline in…Development of a Nationwide Parkinson’s Disease Cohort in Korea: Toward an Ethnicity-Specific Precision Medicine Platform
Objective: To establish and longitudinally expand a nationwide Parkinson’s disease (PD) cohort in Korea (K-PD cohort) and develop an ethnicity-specific precision medicine platform integrating clinical,…Longitudinal Decline of Alanine Aminotransferase Activity in Parkinson’s Disease and Its Association with Disease Duration
Objective: To characterize longitudinal trajectories of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activity and the neutrophil-to-lymphocyte ratio (NLR) in Parkinson’s disease (PD) and healthy…
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