Quality of life and patient reported outcomes with subcutaneous levodopa/carbidopa infusion: Findings from the ND0612 BeyoND study
Objective: To review quality of life and other patient reported outcomes data from the ND0612 BeyoND study. Background: ND0612 is in development as a continuous,…Impact of istradefylline on the adjustment of levodopa dose escalation in Parkinson’s disease: Results of the ISTRA ADJUST PD randomized, controlled study
Objective: To evaluate the effect of istradefylline (IST), an adenosine A2A receptor antagonist, on the adjustment of levodopa dose escalation in patients with Parkinson’s disease…Computer vision can detect changes in bradykinesia associated with dopaminergic state in Parkinson’s disease
Objective: To evaluate the classification accuracy of a computer vision-based feature extraction and classifier method to detect changes in finger tap bradykinesia associated with dopaminergic…A case with clinical features of alpha-synuclein- and tauopathy: Genetic and histopathological workup.
Objective: Here, we present a clinical case that mimicked the coincidence of idiopathic Parkinson’s disease (PD) and tauopathy. Background: Mutation in leucine-rich-repeat-kinase 2 (LRRK2) gene…Multimodal mechanistic disease stratification in sporadic Parkinson’s disease
Objective: To mechanistically stratify Parkinson’s disease (PD), applying a combination of putaminal 31Phosphorus magnetic resonance spectroscopy (31P-MRS) with detailed assessment of mitochondrial and lysosomal function…Concomitant Medication Use and Levodopa Equivalent Daily Dose Requirements After Foslevodopa/foscarbidopa Initiation
Objective: To evaluate patterns of concomitant medication use and levodopa equivalent daily dose (LEDD) during a 52 week study with foslevodopa/foscarbidopa (LDP/CDP). Background: LDP/CDP is…White matter microstructural differences between essential tremor and Parkinson’s disease evaluated using advanced MRI biomarkers
Objective: To study white matter differences between essential tremor (ET) and Parkinson’s disease (PD) using standard diffusion tensor magnetic resonance imaging (DTI) and fixel-based analysis.…Adrenergic blockers and statins are associated with later age of onset in Parkinson’s disease
Objective: To evaluate the association of anti-hypertensives, non-steroidal anti-inflammatories (NSAIDs), statins, diabetes medications, smoking and family history of idiopathic Parkinson’s disease (iPD) with age of…Characterization of neuromelanin MRI as a potential Parkinson’s Disease biomarker in a multi-site longitudinal study
Objective: To investigate (1)longitudinal change and (2)cross-sectional vendor differences in neuromelanin MRI in substantia nigra pars compacta(SNpc) in PD patients. Background: Neuromelanin(NM) MRI is a…Dopaminergic modulation of express reaching responses in Parkinson’s disease
Objective: This study investigates the role of dopamine (DA) in modulation of automatic stimulus-driven responses. We investigated the effect of PD, DA medication, and instruction…
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