Demographic, clinical and genetic factors affecting amantadine response among patients with Parkinson disease
Objective: To identify factors that correlate with efficacy and tolerability of amantadine to predict therapeutic outcomes Background: Amantadine is the only commercially available medication to…Substantia Nigra blood-brain barrier opening in Parkinson´s disease: PET (18F-Choline) evidence of parenchymal penetration
Objective: To evaluate clinical safety, feasibility, and tissue penetration (by 18F-Choline PET) of MR-guided focused ultrasound (MRgFUS) blood-brain barrier opening (BBB-O) of the substantia nigra…Identification of pre-frailty in the elderly through serum metabolomics and its impact on Parkinson’s disease phenotype
Objective: We attempted to better characterize pre-frailty using serum metabolomics in a large cohort of elderly subjects without neurodegenerative diseases. Next, we sought to investigate…Relationship between sleep quality, fear of fall and falls history in people with Parkinson’s disease
Objective: We aimed to investigate the relationship of sleep quality with falls and fear of fall (FOF) in people with Parkinson's disease (PwPD). Background: Fall…Long term effects of Deep Brain Stimulation on Camptocormia in Parkinson’s disease
Objective: Camptocormia (CC) as a syndrome often is a major burden for patients with Parkinson’s Disease (PD). In the absence of response to levodopa (except…Comparative whole transcriptome analysis of human and mice models of Parkinson’s disease bearing defective glucocerebrosidase activity revealed alteration of expression profile of genes involved in the autophagy
Objective: To identify potential biomarkers of Parkinson's disease (PD) associated with dysfunction of enzyme glucocerebrosidase (GCase) by a comparative whole transcriptome analysis of animal models…Single-center experience of deep brain stimulation (DBS) surgery in Malaysia
Objective: We aimed to characterize the DBS cohort and outcomes at a quaternary medical centre in Malaysia. Background: Deep brain stimulation s an established treatment…Extent of cognitive impairment in Parkinson`s disease with Covid-19
Objective: To study of the extent of cognitive impairment in PD patients with Covid-19. Background: Covid-19 may aggravate the clinical course of Parkinson's disease (PD)…The cause of death in Parkinson’s disease
Objective: To investigate the causes of death in patients with Parkinson's disease at 6 hospitals in Kagawa Prefecture, Japan. Background: Not much literature exists on…Long-term effects of a mobile technology-based brisk walking program on Parkinsonian symptoms in Parkinson’s disease – a randomized controlled trial
Objective: To evaluate the effectiveness of a 6-month mobile technology-based brisk walking program on motor and non-motor symptoms and self-perceived ability in people with Parkinson’s…
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