Circuit Malfunctions Undetectable by DBS Programmers: Role of Intraoperative Direct Measurement of Impedance
Objective: This study aimed to clarify the clinical features of these cases Background: Several case reports have described electrical conduction abnormalities that were undetected by…Cognitive Trajectories After STN DBS in Parkinson’s Disease: 12-Month Outcomes
Objective: To determine whether early postoperative cognitive changes occur across distinct domains following STN-DBS Background: Deep Brain Stimulation (DBS) of the subthalamic nucleus (STN) is…Identification of Digital Measures of Motor Progression from In-Clinic Assessments in Early Parkinson’s Disease for Composite Digital Biomarkers: Results from WATCH-PD
Objective: To identify sensor-based digital measures of motor function that exhibit reliability, association with MDS-UPDRS Part 3, and longitudinal progression in early-stage Parkinson’s disease (PD),…Pharmacoscintigraphic Evaluation and Safety of a Novel, Dual-pulse, Delayed-release carbidopa/levodopa Tablet for Bedtime Dosing
Objective: To characterize the pharmacokinetics (PK) of carbidopa (CD) and levodopa (LD) from delayed-release (DR) tablets intended for bedtime administration and to correlate systemic exposure…Activation of the MT1 Receptor Ameliorates Mitochondrial Dysfunction in MPP+/MPTP-Induced Parkinson’s Disease
Objective: This study aimed to explore the role of melatonin receptor 1 (MT1) in improving mitochondrial dysfunction in MPP⁺/MPTP-induced PD models and to clarify the…Assessing the Feasibility of a Multimodal Control Model for Deep Brain Stimulation in Parkinson’s Disease: A Structured Literature Review
Objective: To assess the scientific rationale and feasibility of a multimodal control paradigm for closed-loop deep brain stimulation (DBS) in Parkinson's disease (PD) that combines…A National Interprofessional Model for Parkinson’s Disease Education: Over 20 Years of Collaborative Learning Across the Veterans Health Administration
Objective: To describe a national interprofessional education model for Parkinson's disease across the Veterans Health Administration. Background: In 2000, Congress urged the VHA to establish…Integrative Analysis of GBA1 Mutations and GCase Deficiency in Parkinson’s Disease using Long Read Nanopore Sequencing
Objective: To sequence the GBA1 gene in PD patients with reduced GCase activity using nanopore amplicon-targeted sequencing.To characterize benign, VUS, and pathogenic GBA1 variants. Background:…Prasinezumab’s Impact on Neuromelanin- and Iron-Sensitive MRI Biomarkers in Parkinson’s disease: Findings From the PADOVA Phase IIb Study
Objective: To evaluate the effects of prasinezumab on neuroimaging biomarkers in individuals with early-stage Parkinson’s disease (PD) on stable symptomatic medication. Background: PD is characterized by the…Continuous Subcutaneous Apomorphine Infusion in Parkinson Disease: Final Data from the Multi-Year InfusON Open-Label Extension Study
Objective: Report outcomes from the multi-year extension to the 52-week open-label InfusON study (NCT02339064)1 of continuous subcutaneous apomorphine infusion (CSAI). Background: The US phase 3…
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