Levodopa–Entacapone–Carbidopa Intestinal Gel (LECIG) Provides Sustained Improvement In Quality Of Life In Advanced Parkinson’s For Up To Two Years
Objective: To describe changes in health-related quality of life (QoL), assessed using the 8-item Parkinson’s Disease Questionnaire (PDQ-8), in people with advanced Parkinson’s disease (aPD)…Clinical and Programming Parameter Comparison of STN and GPi Deep Brain Stimulation Targets in Parkinson’s Disease
Objective: To compare subthalamic nucleus (STN) and globus pallidus internus (GPi) deep brain stimulation targets in Parkinson’s disease (PD) regarding demographic characteristics, preoperative cognitive profile,…Face Pareidolia in the East London Parkinson’s Disease Project
Objective: To determine the prevalence of pareidolic illusions in participants enrolled in the East London Parkinson’s Disease (ELPD) Project using the Noise Pareidolia Task (NPT),…Frequency-Specific Effects of SMA-rTMS on Gait Initiation in Parkinson’s Disease
Objective: To compare the effects of 25Hz (facilitatory) and 1Hz (inhibitory) repetitive transcranial magnetic stimulation (rTMS) over the supplementary motor area (SMA) on gait initiation…A Systematic Review and Meta-Analysis of the Diagnostic Accuracy of Fluid Biomarkers in Parkinson’s Disease
Objective: Analyze current efforts and quality of fluid and tissue biomarkers in Parkinson’s Disease (PD) to offer insight into their utility for diagnosis vs healthy controls (HC). Background: Alpha-synuclein is emerging as the leading biomarker…Impact of Helicobacter pylori Eradication on MDS-UPDRS Part III Motor Score in Patients With Parkinson’s Disease A Prospective Cohort Study in Northern Mexico
Objective: To determine the effect of Helicobacter pylori (H. pylori) eradication therapy on the Movement Disorder Society–Unified Parkinson’s Disease Rating Scale (MDS-UPDRS) Part III motor…Unraveling Kinase-Phosphatase Dysregulation in Parkinson’s disease Peripheral Blood Mononuclear Cells Through Targeted Transcript Analysis
Objective: To probe kinase-phosphatase dysregulation and peripheral biomarker potential in peripheral blood mononuclear cells (PBMCs) via LRRK2 (kinase), PPM1H and PP2A (phosphatases), LC3 (autophagy), and…Development and initial feasibility of a Randomised Pilot Trial of Enhanced Tai Chi for Parkinson’s Disease
Objective: To describe the design and feasibility of a randomised controlled pilot study evaluating an Enhanced Tai Chi intervention for people with Parkinson’s disease (NCT07297368).…External Validation of Reported Clinical Predictors of Levodopa-Related Adverse Drug Reactions in Parkinson’s Disease
Objective: To assess the predictive value of previously reported clinical and demographic predictors for levodopa-related adverse drug reactions in the Dutch multicenter Profiling Parkinson’s disease…Decentralized Clinical Trial of a Phase 3 Light Therapy Device for Parkinson’s Disease: Feasibility, Safety, and Efficacy
Objective: To demonstrate the feasibility of an entirely remote, decentralized clinical trial and evaluate the efficacy and safety of a light therapy device to treat…
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