Evaluation of a double-target therapeutic in preclinical models of Parkinson’s disease
Objective: To evaluate the effectiveness of a candidate compound identified in a high-throughput screening (HTS) assay carried out in a Drosophila model of Parkinson’s disease…Inhibition of GluN2D-containing NMDA receptors alleviates the loss of dopaminergic neurons and behavioral deficits in 6-OHDA-induced model of Parkinson’s disease
Objective: The aim of this study is to explore whether the inhibition of GluN2D-containing NMDA receptors (NMDAR2D) can delay the pathological manifestations of Parkinson's disease…Time to diagnosis of clinically established Parkinson’s disease or atypical parkinsonism: is a 5-year follow-up period necessary?
Objective: To determine the time frame to the diagnosis of clinically established Parkinson’s disease (PD) or atypical parkinsonism after an acute levodopa challenge (LDC) for…Rapidly progressive dementia after MRI-guided Focused Ultrasound (MR-FUS)
Objective: To present a Parkinson´s Disease (PD) patient who presented a rapidly progressive dementia after MR-FUS therapy. Background: MR-FUS thalamotomy is used for unilateral essential…Mild cognitive impairment does not predict development of dementia up to 15 years after subthalamic deep brain stimulation in Parkinson’s disease
Objective: This is a long-term follow-up study of a group of patients with levo-dopa responsive fluctuating Parkinson’s disease (PD), with focus on the short- and…Prognostic Modeling of Parkinson’s Disease Progression Using Early Longitudinal Patterns of Change
Objective: To develop a prognostic model using multiple longitudinal measures to predict temporal clinical progression in early PD. Background: Predicting time to Parkinson’s disease (PD)…The Commercial Genetic Testing Landscape for Parkinson’s Disease
Objective: To evaluate commercial genetic testing offered for Parkinson’s disease (PD) Background: The etiology of PD is complex and, typically, multifactorial. At least 6 genes…Increased stroke risk in Parkinson’s disease patients with LRRK2 mutations
Objective: To determine whether genetic forms of Parkinson’s Disease (PD), such as LRRK2-mutated PD (LRRK2-PD) and GBA-mutated PD (GBA-PD), have a different vascular risk compared…Parkinson’s Families Project: analysis of a large cohort of patients with early onset and familial Parkinson’s disease
Objective: We aim to identify new gene variants associated with familial and early-onset Parkinson's disease (PD), through genetic comparison of affected and unaffected family members.…Effects of fine particulate matter and cigarette smoking on MPTP-induced dopaminergic neuronal cell death: Implication for Parkinson’s disease
Objective: The objective of this study was to determine the potential neurotoxicity of fine particulate matter (FPM) and the neuroprotective properties of nicotine in the pathogenesis…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.