Coping with Parkinson’s Disease through the Lens of Personality Systems Interactions (PSI) Theory: Two Case Studies
Objective: This study examines how concepts from motivation and personality research contribute to understanding coping strategies in individuals with Parkinson’s disease (PD). Background: Effective treatment…Mitigating Risk and Expanding Movement Disorder Specialist Capacity: Advancing Parkinson’s Disease Management with Integrated Monitoring, Targeted Triage and Improved Patient-Clinician Communication in Parkinson’s Disease.
Objective: Empower patients with exercise-focused motivational frameworks and personalized tracking for real-time health insights, while reducing clinician burden through continuous monitoring and targeted health coaching—all…Early Introduction of COMT Inhibitors at Low Levodopa Doses Improves Long-Term Motor Complications in Parkinson’s Disease: A sub-analysis of the REONPARK Study
Objective: This sub-analysis of the REONPARK study aims to identify predictive factors for the greater effectiveness of COMT inhibitors (COMTi) in alleviating motor complications in…Repetitive Transcranial Magnetic Stimulation For Freezing Of Gait And Motor Function In Parkinson’s Disease: A Systematic Review And Meta-Analysis Of Randomized Controlled Trials
Objective: To evaluate the effects of repetitive transcranial magnetic stimulation (rTMS) on motor function, freezing of gait (FOG), and mobility in patients with Parkinson’s disease…Unraveling the Intertwined Relationship of DBS, Parkinson’s Disease Subtype and LEDD: A Retrospective Study
Objective: To assess the impact of deep brain stimulation (DBS) target and Parkinson’s disease (PD) motor subtype on the total levodopa equivalent daily dose (LEDD)…Therapeutic Potential of GLP-1 Receptor Agonists in Parkinson’s Disease: A Systematic Review and Meta-Analysis
Objective: To assess the safety and effectiveness of GLP-1 RAs in patients with PD. Background: Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by…Individual physiomarkers of levodopa-induced local field potential fluctuations interact with deep brain stimulation in Parkinson’s disease
Objective: We investigated the behavior of LFPs in 57 patients across therapeutic states using a data-driven method to find personalized physiomarkers. Background: The power of…Phase 1 and 1b Pharmacodynamic Data Support Central Modulation of Lysosomal Pathways With BIIB122/DNL151, a LRRK2 Kinase Inhibitor: Insights for the LUMA Trial
Objective: Evaluate the effects of BIIB122/DNL151 treatment on CSF levels of pRab10, a biomarker of CNS LRRK2 modulation, in a Phase 1 study in healthy…Identification of Rigidity in Parkinson’s Disease Using Wearable Technology
Objective: To evaluate the capacity of upper limb kinematic measures, collected using wearable technology, in (a) capturing clinical rigidity in Parkinson’s disease (PD) and (b)…1H-NMR and UPLC/MS Metabolomics Identify Disrupted Homeostasis of Energy, Amino Acids, and Glutathione Metabolism as Serum Signatures in Parkinson’s Disease Patients
Objective: We sought to identify a signature distinctive of Parkinson’s disease (PD) through two independent metabolomics approaches. Background: A recent meta-analysis showed a considerable inconsistency…
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