A Tiered Fecal Biomarker Approach to Identify Gut–Brain Axis Phenotypes in Young-Onset Parkinsonism in a Clinical Setting with Limited Resources
Objective: To explore the feasibility of a tiered fecal biomarker testing approach to identify potential gut–brain axis phenotypes in patients with young-onset parkinsonism in a…Baseline auditory-perceptual speech ratings predict improvement in voice intensity after group-based speech intervention in Parkinson’s disease
Objective: To explore baseline predictors of improvement in voice intensity following group-based speech intervention in PD. Background: Speech and voice impairments are common in PD…Endogenous reproductive factors and risk of Parkinson’s disease in women: a systematic review and meta-analysis of observational studies
Objective: To provide an updated synthesis of existing evidence and critically appraise previous methodological approaches, we conducted a systematic review and meta-analysis of observational studies…ITSN1 Loss-of-Function variants and Parkinson’s disease risk in a Chinese cohort
Objective: To replicate and validate the association between ITSN1 loss-of-function (LoF) variants and Parkinson's disease (PD) in a Chinese population, and to assess whether this…Cerebrospinal Fluid Markers are associated with Cognitive Decline in GBA1-associated Parkinson’s Disease
Objective: To analyze whether and how cerebrospinal fluid (CSF) amyloid-related markers relate to the longitudinal cognitive profile in PD-GBA1. Background: Cognitive decline in Parkinson’s disease…EEG-based Functional Connectivity Reveals a Genotype-Specific Network Signature in GBA-Associated Parkinson’s Disease
Objective: to investigate whether PD patients carrying pathogenetic GBA variants exhibit distinct frequency-specific EEG-based FC alterations compared with GBA1-negative PD patients (PD-GBA−). Background: Variants in the GBA1 gene…Clinical Drug-Drug Interaction Profile Of BIA 28-6156: Results From Three Independent Phase I Studies
Objective: Three independent, open-label, clinical drug-drug interaction (DDI) studies were conducted to characterise the clinical DDI profile of BIA 28-6156. Background: BIA 28-6156 (paricerat) is…Age-Related Hearing Loss in Idiopathic Parkinson’s Disease and APOE E4 Carriers
Objective: Identify whether APOE E4 modulates the relationship between age and hearing loss in idiopathic Parkinson’s disease (PD). Background: Hearing loss is associated with increased…Aggregation – Dependent Effects of Wild-Type and Mutant α-Synuclein on Synaptic Membrane Fusion
Objective: 1. What is the endogenous form of ⍺-Synuclein in various cell types?2. How do WT ⍺-Synuclein monomer and aggregates affect presynaptic membrane fusion and the…Sublingual apomorphine for parkinsonian tremor: Post-hoc analysis of pivotal trial data
Objective: We explored tremor outcomes associated with apomorphine sublingual film (SL‑APO) in patients with a tremor‑dominant PD phenotype. Background: Tremor is a common and disabling…
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