Quantitative Susceptibility Mapping Revealed Regional Iron Alteration and As a Biomarker for Dopaminergic Deficits in Parkinson’s Disease
Objective: This study aimed to identify regions with altered brain iron accumulation using quantitative susceptibility mapping (QSM) and to investigate the association between iron deposition…LRRK2 in Focus: A Global Browser Linking Genetic Diversity to Functional Effects
Objective: To develop a publicly accessible web browser that allows users to easily explore the distribution of LRRK2 variants in both Parkinson’s disease (PD) and…Voice-Based Screening of Parkinsonian Disorders Using Acoustic Feature Analysis and Machine Learning
Objective: To evaluate whether acoustic features from voice recordings can distinguish Parkinson’s disease and related parkinsonian disorders from healthy controls. Background: Speech production depends on…Clinical Underestimation of Wearing-Off in Parkinson’s Disease: Patient-Reported Outcomes Versus Clinical Assessment and Impact on Quality of Life
Objective: To prospectively investigate the frequency and determinants of wearing-off (WO) in Parkinson's disease (PD) using a validated patient-reported instrument compared to routine neurological evaluation,…Occupational Pesticide Exposure, Personal Protective Equipment, and Parkinson’s Disease: An Observational Study from the PPMI Cohort
Objective: To evaluate the association between occupational exposure to specific pesticides and Parkinson’s disease in participants from the PPMI Online cohort, and to determine whether…Beyond Motor Symptoms: Utilizing the FreeSurfer Brainstem Substructures Module to Characterize a Complex Parkinsonian Phenotype with Profound Dysautonomia
Objective: To describe the autonomic function profile and quantitative brainstem substructures analysis in a 62-year-old male of Parkinsonism complicated by severe autonomic failure and neuropsychiatric…Genome-wide Discovery of GBA1 Modifiers in Parkinsons Disease Carriers across Populations from the Global Parkinsons Genetics Program
Objective: To identify genetic risk modifiers for GBA1 risk variant carriers of European and African ancestry, we used data from GP2 (http://gp2.org/), the UK Biobank,…Bridging Genetics and Precision Medicine in Parkinson’s Disease through GP2: Translating Genetic Risk into Trial-Eligible GBA1 and LRRK2 Cohorts
Objective: To advance precision medicine in Parkinson’s disease (PD) by integrating large-scale clinico-genetic data from diverse populations worldwide and establishing a framework to characterize individuals…Towards Deep Learning for Personalized Parkinson’s Disease Tremor Segmentation and Severity Classification Using Wearable Sensors
Objective: The objective of this work is to develop and evaluate a deep learning framework for segmenting and classifying Parkinson’s disease (PD) resting tremor severity…Comparison of Non-Motor Outcomes after Subthalamic Nucleus versus Globus Pallidus Internus Deep Brain Stimulation in Parkinson’s disease
Objective: To compare non-motor symptom outcomes after globus pallidus internus (GPi) versus subthalamic nucleus (STN) deep brain stimulation (DBS) in Parkinson’s disease (PD). Background: Non-motor…
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