Non-motor Symptoms in Parkinson Disease: A Target for Neuropalliative Care Intervention
Objective: To identify various non-motor symptoms experienced by individuals with PD and to assess the likelihood of these symptoms being treated relative to individuals without…Dose Optimization of Foslevodopa/Foscarbidopa: Post Hoc Analysis of Study Completers
Objective: To describe dose optimization, efficacy, and safety of foslevodopa/foscarbidopa (LDp/CDp) in patients with advanced Parkinson’s disease (PwaPD) who completed a 52-week open-label study. Background:…Effect of Opicapone on Sleep-Related Complaints and Non-Motor Burden in Parkinson’s Patients: A Post-Hoc Analysis of the OASIS Trial
Objective: To assess the effect of opicapone (OPC) on different sleep complaints and non-motor symptoms (NMS) in fluctuating Parkinson’s disease (PD) patients with sleep disturbances.…Unilateral focused ultrasound subthalamotomy in early Parkinson’s disease: randomized-controlled trial protocol
Objective: To describe the protocol of a multicenter, prospective, randomized controlled trial (EarlyFocus II) which evaluates the efficacy and safety of unilateral magnetic resonance-guided focused…Harnessing Digital Biomarkers to Monitor Early Parkinson’s Disease Progression
Objective: This study aimed to identify gait metrics capable of capturing disease progression in individuals with early Parkinson’s disease (PD). Background: Digital gait assessments have…Efficacy and Safety of IPX203 and Levodopa-Carbidopa Intestinal Gel (LCIG) Compared to Immediate-Release Carbidopa-Levodopa in Parkinson’s Disease: A Systematic Review and Meta-Analysis
Objective: To conduct the efficacy and safety of IPX203, an extended-release carbidopa-levodopa formulation, and LCIG, a continuous levodopa infusion, compared to Immediate-Release Carbidopa-Levodopa (IR CD-LD)…Solengepras: An Investigational Therapy with Potential Benefits on Functional and Non-Motor Measures in Parkinson’s Disease (PD)
Objective: Solengepras is a GPR6-inhibitor that is being studied as an investigational treatment for Parkinson’s Disease (PD). Background: GPR6 is a novel G-protein-coupled receptor found…Advancements in Microbiome Research: Total Microbial Load, Differential Absolute Abundance, and Correlations with Immune Transcriptomics
Objective: Quantify total microbial load in the gut microbiome of people with Parkinson’s disease (PD) and compare the absolute abundance of bacterial taxa between PD…A novel virtual home-safety fall prevention program for Parkinson’s Disease
Objective: To determine the feasibility and preliminary efficacy of a novel virtually-delivered protocol targeting extrinsic environmental fall risk factors in the homes of persons with…Istradefylline for Freezing of Gait in Parkinson’s Disease: A Systematic Review and Meta-Analysis
Objective: To evaluate the effects of istradefylline on motor function and freezing of gait (FOG) in patients with Parkinson’s disease (PD). Background: FOG is a…
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