Gut Microbiome Metagenomics in Parkinson’s Disease Stratified by the Asian-Prevalent LRRK2 Variants p.G2385R and p.R1628P
Objective: To compare gut microbiome profiles of manifesting LRRK2 p.G2385R or p.R1628P carriers (LRRK2-PD) and idiopathic Parkinson’s disease patients (iPD). Background: Leucine-rich repeat kinase 2…Prevalence and clinical predictors of depressive symptoms in Parkinson’s Disease: an analysis from the Global Parkinson’s Genetics Program
Objective: To estimate the prevalence and distribution of depressive symptoms in PwP and identify demographic and clinical factors associated with depression across European cohorts available…Clinical Outcomes and Safety of Ablative Surgery for Parkinson’s Disease in Resource-Limited Settings: A Cohort from Indonesia
Objective: To evaluate the clinical outcomes and safety of ablative surgery for Parkinson’s disease at Indonesia’s national tertiary referral neurological center. Background: Deep brain stimulation…Effect of Poor Sleep Quality on Fatigue Severity in Parkinson’s Disease
Objective: To investigate the effect of poor sleep quality on fatigue severity Background: Poor sleep quality is observed in 60% of Parkinson's Disease (PD). The…Dentate Glutamate as an OFF-State Biomarker of Levodopa-Resistant Postural Tremor in Parkinson’s Disease
Objective: This study aims to ascertain whether OFF-state dentate nucleus glutamate, measured using J-difference edited MRS, predicts residual postural tremor following levodopa in Parkinson’s disease…Multimodal Quantitative MRI Improves Parkinson’s Disease Classification
Objective: To evaluate multimodal MRI discrimination of Parkinson’s disease using RPCA–kNN and associations with MDS-UPDRS. Background: Parkinson’s disease (PD) involves progressive neurodegeneration affecting basal ganglia…Non‑Motor Outcomes after STN-FUS for Parkinson’s disease
Objective: To assess changes in non-motor symptoms(NMS) in PD after focused ultrasound subthalamotomy(STN-FUS). Background: NMS impair quality of life in PD.STN-FUS improves motor signs in PD but…Elevated Myeloperoxidase Levels and Activity as Potential Biomarkers for Parkinson’s Disease: A Systematic Review and Meta-Analysis
Objective: To assess the utility of the myeloperoxidase enzyme level as a diagnostic biomarker in Parkinson’s disease. Background: Myeloperoxidase (MPO) contributes to Parkinson’s disease (PD)…Validation of Instrumented Finger Tapping Metrics for Bradykinesia in Parkinson’s disease
Objective: To validate quantitative metrics using goniometer and TAS test video-based finger tapping in Parkinson’s disease. Background: Clinical assessment of finger tapping in Parkinson's disease…Impact of Alpha-Synuclein Burden and Cellular Stress on GBA-PD Macrophage
Objective: This study explores how non-neuronal dysfunction drives the rapid progression of GBA-PD, aiming to identify therapeutic targets that restore protein degradation and cellular stability.…
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