GLP1R Expression and Parkinson’s Disease and Related Disorders in GLP-1RA–Treated Type 2 Diabetes
Objective: We tested whether interindividual differences in systemic GLP1R expression are associated with PDRD risk among adults with type 2 diabetes initiating GLP-1RAs. Background: Preclinical…Decoding Parkinson’s Disease Metabolic Landscape: Targeted 4D-Metabolomics of Urinary Amine-Phenol Submetabolomes for Specific Signature Identification and Biomarker Discovery
Objective: To develop a non-invasive diagnostic strategy for Parkinson’s disease (PD) via targeted 4D-metabolomics, identify PD-specific urinary amine-phenol biomarkers, and explore PD-related metabolic mechanisms. Background:…Feasibility of the ActivPARK Study – Longitudinal Assessment of Physical Activity in People with Parkinson’s Disease
Objective: To evaluate the feasibility designed to inform a future national cohort study assessing physical activity (PA) and health longitudinally in people with Parkinson’s disease…Cerebrospinal Fluid Metabolic Alterations Reveal a Central Energy Metabolism Shift in Parkinson’s Disease
Objective: To comprehensively characterize central energy metabolism in Parkinson’s disease (PD) through cerebrospinal fluid (CSF) metabolomic profiling. Background: We previously reported weight loss and systemic…Opicapone as adjunct to levodopa in Chinese patients with Parkinson’s disease and wearing-off: a randomized, double-blind, placebo-controlled phase 3 trial
Objective: To evaluate the efficacy and safety of once-daily opicapone as adjunct to levodopa in Chinese patients with Parkinson’s disease (PD) and wearing-off, and to…Rare GBA c.1157T>G (p.F386C) Variant in Parkinson’s Disease. Case study.
Objective: To describe the clinical phenotype of a patient with Parkinson's disease who carries a rare heterozygous variant of GBA c.1157T>G (p.F386C) and to analyze…Risk stratification study of fluid biomarkers for alpha-synucleinopathy with dementia
Objective: This study focuses on mixed pathology of α-synucleinopathy and Alzheimer’s disease(AD), analyzing the relationships among biomarkers, genetic factors, and cognitive function in order to…Urine and Plasma Bis(monoacylglycero)phosphate (BMP) in Asian LRRK2 p.G2385R and p.R1628P Variant Carriers with Parkinson’s Disease
Objective: To compare urine and plasma bis(monoacylglycero)phosphate (BMP) levels in Parkinson disease (PD) patients carrying Asian-prevalent LRRK2 variants (p.G2385R, p.R1628P) against idiopathic PD (iPD) and…Subtle Behavioral Changes Observed by Knowledgeable Informants Up to Decades Before Parkinson’s Disease Diagnosis
Objective: To characterize subtle behavioral changes observed by Knowledgeable Informants (KIs) of people with Parkinson’s disease (PwPD) before diagnosis. Background: Earlier identification of PD remains…Long-term safety of deep brain stimulation (DBS): Real-world evidence
Objective: In this analysis, we aimed to evaluate long-term safety of DBS systems in real-world use. Background: Deep brain stimulation (DBS) is an established therapy for…
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