Exploring the ubiquitome in Parkinson’s Disease
Objective: To explore the role of ubiquitin signalling defects in Parkinson’s Disease. Background: Defects in ubiquitin signalling have been implicated in the pathogenesis of neurodegenerative…Apolipoprotein E ɛ4-allele and Amygdala Atrophy in Parkinson’s Disease: A Preliminary Longitudinal Analysis from the ONDRI Cohort
Objective: To investigate the association of apolipoprotein E ɛ4-allele (APOE-ε4) with amygdala volumes longitudinally in Parkinson’s disease (PD). Background: APOE-ε4 is a genetic risk factor…Exploring Neuroprotective Role of Natural Compound by Targeting c-Abl Kinase in Parkinson’s Disease
Objective: To explore c-Abl kinase activation and neuron death pathway in Parkinson’s Disease (PD) mouse model. Assess neuroprotection natural compounds, Rosmarinic acid (RA) with proven…Evaluation of Perfusion, Iron Deposition, and Neuromelanin MRI Biomarkers Following Mesenchymal Stem Cell Treatment in a Phase 2 Parkinson’s Disease Trial
Objective: Evaluate the effects of allogeneic bone marrow-derived mesenchymal stem cell (allo-hMSC) infusions on neuroimaging biomarkers in patients with Parkinson’s disease (PD) using different MRI…Subthalamic nucleus DBS outcomes correlate with white matter tractography in Parkinson’s Disease
Objective: To assess whether advanced diffusion magnetic resonance imaging (dMRI) techniques help to understand the outcome of Deep brain stimulation (DBS) surgery on Unified Parkinson’s…Understanding the relationship between synaptic density and dopamine transporter availability in Parkinson’s disease
Objective: To evaluate how disease duration in PD affects the coupling of DAT (18F-FE-PE2I) and SV2A density (11C-UCB-J) in the nigrostriatal regions (where both tracers…Assessing the potential association of rs2298383 in ADORA2A as a predictor of Levodopa-Induced Dyskinesia in Latin American Parkinson’s Disease patients
Objective: To analyze the association between ADORA2A-rs2298383 and levodopa induced dyskinesias (LID) in a cohort of Latin American Parkinson’s disease patients. Background: Previous evidence has…Insights into Genetic Counseling Recall and Clinical Trial Interest in PD GENEration
Objective: To assess the impact of participation in PD GENEration, a large-scale genetic and counseling study for Parkinson’s disease (PD). We evaluated the recall of…Linking Adolescent Brain Development To Parkinson’s Disease Risk Using Machine Learning On Polygenic Risk Scores
Objective: Examine whether adolescent brain structural deviations contribute to Parkinson’s disease (PD) susceptibility. Background: Genetic variants associated with PD have been linked to neurodevelopmental processes,…Improving Recruitment of Black and African American Participants in Parkinson’s Genetics Research
Objective: To describe recruitment methods and lessons learned to date in the BLAAC PD study. Background: Diversity in Parkinson’s disease (PD) research is largely lacking.…
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