A Distinct Genetic Landscape of Progressive Supranuclear Palsy in Asians: Beyond the MAPT-Dominant Paradigm
Objective: To delineate the genetic architecture of progressive supranuclear palsy (PSP) in a large, multicenter, multinational Asian cohort using whole-exome sequencing (WES) and investigate the…App-Based Speech Assessment Differentiates PD and PSP: A Feasibility Study in Italian Speakers
Objective: To evaluate the feasibility of app-based speech assessment in Parkinson’s disease (PD) and progressive supranuclear palsy (PSP), and to explore group differences in speech…Role of florzolotau (18F) positron emission tomography in the diagnosis and clinical management of progressive supranuclear palsy: a real-world study
Objective: This study aimed to evaluate the diagnostic utility of florzolotau (18F) positron emission tomography (PET) and its impact on therapeutic decision-making in patients with…Comparison of Regional Perfusion Patterns in Clinical Subtypes of PSP and CBD: Dual Phase [¹⁸F]FP CIT PET Study
Objective: To investigate the regional perfusion patterns using PET imaging across various clinical subtypes of PSP and CBD. Background: On MRI, PSP typically shows midbrain…Validation of the Short Progressive Supranuclear Palsy Quality of Life Scale in PSPNI
Objective: This study aimed to evaluate the reliability, validity, and sensitivity to change of the PSP-ShoQoL in PSPNI, a longitudinal Chinese PSP cohort. Background: Self-reported…Quantitative Regional Tau Pathology and Spatial Transcriptomics Identify Signatures of Phenotypic Diversity in Progressive Supranuclear Palsy.
Objective: To determine the pathological and molecular determinants of phenotypic diversity in PSP. Background: PSP exhibits broad variability in clinical phenotype and progression, however the…Utilizing the 15-item modification of the PSPRS rating scale (mPSPRS-15) as the primary endpoint for future clinical trials in progressive supranuclear palsy
Objective: To compare the properties of PSPRS-28, mPSPRS-15, and the rPSPRS-10 and assess their utility as a primary endpoint in PSP trials. Background: Progressive supranuclear…Concomitant Progressive Supranuclear Palsy and Amyotrophic Lateral Sclerosis Versus Motoneuron Phenotype of PSP in Ukrainian Patient
Objective: To provide a description of a rare case of mixed progressive supranuclear palsy (PSP) and amyotrophic lateral sclerosis (ALS) in Ukrainian patient. Background: The…Brain Cholinergic Changes in Progressive supranuclear palsy: A single-subject voxel-wise approach to understanding heterogeneity
Objective: To characterize individual-level topographical patterns of cholinergic changes compared to controls in Progressive Supranuclear Palsy (PSP) using a voxel-wise approach. Background: The cholinergic system…The IMPACT study: protocol of a randomised controlled single-blind trial evaluating efficacy and cost-effectiveness of telenursing in atypical parkinsonism
Objective: To present the protocol of a study evaluating the efficacy and cost-effectiveness of a 12-month integrated program aimed at improving healthcare delivery and coordinated…
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