Ginsenoside Rb1 protects dopaminergic neurons through Foxm1-Nurr1 pathway in mice model of Parkinson’s disease
Objective: In the present work, we investigated the protective effects of ginsenoside Rb1 in dopaminergic neurons through Foxm1-Nurr1 pathway in mice model of Parkinson’s disease.…The role of substantia nigra sonography in the differentiation of Parkinson’s disease and multiple system atrophy
Objective: To evaluate the differential diagnosis value of transcranial sonography (TCS) between Parkinson’s disease (PD) and multiple system atrophy (MSA) Background: The differential diagnosis of…Neurohormetic properties of mild physical stress against Parkinson’s disease phenotype
Objective: To test whether routine mild physical stress acts as a hormetic strategy against Parkinsonian symptoms among mice. Background: Regular physical exercise is suggested to…Neuromelanin sensitive MRI of substantia nigra: An imaging biomarker to differentiate essential tremor from tremor-dominant Parkinson’s disease
Objective: We aimed to evaluate whether neuromelanin sensitive MRI (NM-MRI) features in the substantia nigra pars compacta(SNc) were of diagnostic value to differentiate untreated ET…Absence of the nigrosome-1 area in 3 tesla resonance and its relation with hyperechogenicity of the substantia nigra in patients with Parkinson’s disease
Objective: To compare the usefulness of two neuroimaging methods (3TMR and MEcho) to assist in the diagnosis of PD. Background: In patients with Parkinson's disease…Substantia nigra hyperechogenicity is similarly enlarged in Gaucher and in GBA mutation carriers
Objective: Testing the role of glycolipid accumulation in the risk for Parkinson's disease. Background: Increased risk for Parkinson's disease is well known among carriers of…High-mobility group box 1 from astrocytes upregulates TH expression to maintain dopaminergic neurons via JNK pathway in human Parkinson’s disease patients and MPTP induced mouse model
Objective: Supporting by glial cells could be reinforced the function of dopaminergic neurons against extracellular insults in Parkinson’s disease (PD) development. However, we do not…Admixing augments nigral dopaminergic correlates during development to impart resistance to MPTP-toxicity at adulthood
Objective: Establish the developmental basis for varying nigral dopaminergic (DA) correlates in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) susceptible C57BL/6, MPTP resistant CD-1 and their resistant crossbred mice. Background:…Optimization of Synucleinopathy and Nigrostriatal Degeneration Induced by Injection of Alpha-Synuclein Preformed Fibrils into Rat Striatum
Objective: Optimization of the surgical parameters (intrastriatal placement and concentration of alpha-synuclein preformed fibrils; α-syn PFFs) to increase the magnitude of nigrostriatal α-syn pathology and…Curcumin I protect against copper induced neurobehavioral features of Parkinson’s disease in rat
Objective: evaluate the impact of acute Cu intoxication (10 mg/kg B.W. i.p) for 3 days on the dopaminergic system and locomotor performance, together with the…