Macrophage Subtypes in Brainstem Catecholamine Regions in Healthy Ageing and Across Parkinson’s Disease.
Objective: To assess macrophages in the human brainstem in healthy ageing and during Parkinson’s disease (PD). Background: PD is the second most common neurodegenerative disorder…Establishing a Timeline of Non-Motor and Motor Symptoms Progression in Parkinson’s Disease Using a Sub-Chronic MPTP Mouse Model
Objective: Parkinson’s disease (PD) mouse model using 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) was explored for pathological mechanisms driving non-motor symptoms (NMS). Aim was to map the behavioural changes…Analgesic Effect of Cannabidiol and Tetrahydrocannabinol(THC) on Pain Sensitivity in Reserpine Model of Parkinson’s Disease
Objective: The objectives of the study were to determine the effect of THC and CBD on:1. Thermal nociceptive threshold in reserpine induced Parkinson’s disease2. Mechanical…Hemiparkinsonism Induction with 6-OHDA in Primates Does Not Induce SN Hyperechogenicity.
Objective: We aimed to investigate the changes in SN echogenicity in primate models of hemiparkinsonism induced by 6-OHDA. Background: Hyperechogenicity in the midbrain demonstrated by…Substantia Nigra Degeneration In Spinocerebellar Ataxia 2 And 7 Using Neuromelanin-Sensitive Imaging
Objective: To assess substantia nigra pars compacta (SN) degeneration in SCA type 2 and 7 using neuromelanin-sensitive MRI Background: Spinocerebellar ataxias (SCA) are often associated…Two parallel nigrostriatal subcircuits mediate the arousal effect of dopaminergic neurons in substantia nigra pars compacta
Objective: This study systematically investigates the involvement of dopaminergic (DA) neurons in substantia nigra pars compacta (SNc) in wakefulness-sleep regulation and explores the underlying circuit…PARKIN gene replacement by AAV-mediated gene delivery as a therapeutic modality for PARKIN-deficient early-onset familial Parkinson’s disease
Objective: Evaluate PARKIN gene replacement by adeno-associated virus (AAV) vector as a therapeutic modality in relevant disease models of early-onset Parkinson’s Disease (EOPD). Background: Biallelic…The Role of Adaptive Immunity caused by α-synuclein Recognition Specific Sequence Peptide on the Onset of Parkinson’s Disease Pathogenesis
Objective: We investigated whether α-synuclein-derived peptides (recognized specific sequence in α-synuclein) can drive T-cell response and evaluated the neurotoxicity of α-synuclein peptide-specific T-cell in Parkinson’s…Dopaminergic Neuronal attributes in aging Substantia Nigra and Ventral Tegmental Area of mice strains distinctly sensitive to MPTP
Objective: To determine the age-related changes in neuronal morphology in the substantia nigra pars compacta (SNpc) and Ventral Tegmental Area (VTA) of C57BL/6J and CD-1…Comparing neuromelanin intensity estimation techniques for Parkinson’s disease image analysis
Objective: The objective of this study is to compare robust neuromelanin (NM) substantia nigra pars compacta (SN) and locus coeruleus (LC) quantification techniques captured in…
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