MDS Abstracts

Abstracts from the International Congress of Parkinson’s and Movement Disorders.

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Articles tagged "Substantia nigra"

  • 2016 International Congress

    SOD1 aggregation: A pathological link between Parkinson’s disease and amyotrophic lateral sclerosis?

    B.G. Trist, K.M. Davies, S. Genoud, V. Smoothy, G.M. Halliday, S. Roudeau, A. Carmona, L. Perrin-Verdugier, R. Ortega, K.L. Double (Sydney, Australia)

    Objective: To characterize (1) a novel association between superoxide dismutase 1 (SOD1) aggregation and neuronal loss in the Parkinson's disease (PD) brain and (2) the…
  • 2016 International Congress

    AMP kinase regulates ligand-gated K-ATP channels in substantia nigra dopamine neurons

    S.W. Johnson, Y. Wu, A.C. Munhall, K.Z. Shen (Portland, OR, USA)

    Objective: To characterize the effect of AMP-activated protein kinase (AMPK) on ATP-sensitive K+ (K-ATP) channels on substantia nigra compacta (SNC) dopamine neurons in slices of…
  • 2016 International Congress

    Astroglia exert a neuro-protective role in Parkinson’s disease by reducing oxygen stress through dopamine-induced activation of the pentose-phosphate pathway

    K. Mashima, S. Takahashi, T. Iizumi, T. Abe, N. Suzuki (Tokyo, Japan)

    Objective: Although dopaminergic neurons themselves take up most of the released dopamine (DA), a part of the DA appears to be taken up by astroglia.…
  • 2016 International Congress

    Engrailed enhances dopamine synthesis in healthy dopaminergic neurons

    D. Alvarez-Fischer, M. Baaske, F. Vulinovic, J. Fuchs, P. Seibler, A. Rakovic, A. Prochiantz, C. Klein (Lübeck, Germany)

    Objective: The aim of the present study was to further elucidate the role of Engrailed in dopamine neurotransmission. Background: Engrailed1 and Engrailed2, collectively Engrailed, are…
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