Reversible encephalitic Parkinsonism due to bilateral substantia nigra lesion showing preserved nigrostriatal dopaminergic activity
Objective: A case of encephalitic Parkinsonism due to bilateral substantia nigra lesion showing reversible course with preserved nigrostriatal dopaminergic activities. Background: A few cases have…Single-Cell Transcriptomics and Experimental Models Implicate Functional Hypoxia in Microglial DAM Polarization and α-Synuclein Accumulation, with Involvement of HIF-1α, in Parkinson’s Disease
Objective: To investigate whether microcirculatory impairment-induced hypoxia contributes to the emergence of a late-stage disease-associated microglia (DAM) phenotype and impaired α-synuclein clearance in Parkinson's disease…The Relationship Between Substantia Nigra Hyperchogenicity and Clinical Features and Disease Progression in Parkinson’s Disease Patients
Objective: To investigate the relationship between substantia nigra hyperechogenicity (SN+) and clinical features and disease progression in patients with Parkinson's disease (PD) under transcranial sonography…Lipid Alterations in Central Nervous System and Plasma During Early Stages of Parkinson’s Disease
Objective: To identify early lipid alterations in a progressive mouse model of Parkinson’s disease (PD) and to determine whether peripheral lipid signatures reflect lipid changes…Substantia Nigra Free-Water, Metabolic Markers, and Motor Variability in Older Adults with Diabetes
Objective: To examine whether nigral microstructural integrity measured via substantia nigra free-water MRI (FW-MRI) relates to peripheral metabolic burden and motor variability across the glycemic…Investigating Substantia Nigra Microstructural Integrity as a Potential Predictive Biomarker for Fall Burden in Parkinson’s Disease
Objective: Determine whether baseline Diffusion Tensor Imaging (DTI) measures of the substantia nigra (SN) predict fall incidence and burden in Parkinson’s disease (PD). Background: Degeneration of dopaminergic…Delayed Parkinsonism Following Japanese Encephalitis: A Case Report with Dopamine Transporter Imaging and L-dopa/DCI treatment
Objective: To report a case of Japanese encephalitis (JE) presenting with thalamic–midbrain lesions followed by delayed parkinsonism confirmed by dopamine transporter imaging. Background: JE is…The Dual Functional Organization of the Substantia Nigra in Parkinson’s Disease
Objective: We applied connectopic mapping to the internal functional organisation of the substantia nigra (SN) in independent cohorts. Background: The human SN is a central…Association of Neurofilament Light Chain with Substantia Nigra Degeneration in Parkinson’s Disease
Objective: This study aims to investigate the association between serum neurofilament light chain (NfL), microstructural changes in the substantia nigra, and clinical manifestations in Parkinson’s…Analysis of Sphingolipid Metabolism Gene Expression in the Parkinson’s Disease Postmortem Brain Dataset
Objective: To investigate the landscape of sphingolipid metabolism gene expression in Parkinson’s disease (PD).To investigate the landscape of sphingolipid metabolism gene expression in Parkinson’s disease…
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