Open-label extension (OLE) of a multiple ascending dose (MAD) study of BIIB092 in participants with PSP: Safety analysis
Objective: To assess safety of BIIB092 in participants with progressive supranuclear palsy (PSP) in an OLE of a MAD study. Background: BIIB092 is a humanized…Neuropathology of a South Korean with Perry syndrome with DCTN1 T78C mutation
Objective: To analyze macroscopic and microscopic findings of the Korean patient with Perry syndrome (PS), who had been already established about clinical features with genetic…Prevalence and characteristics of patients with progressive supranuclear palsy (PSP) in US health insurance claims data
Objective: To estimate the prevalence of PSP in the United States (US) and present a profile of PSP patients. Background: Progressive supranuclear palsy (PSP) is…Burden of progressive supranuclear palsy: A systematic literature review
Objective: The objective of this research was to identify available data on burden of progressive supranuclear palsy (PSP), a 4-repeat tauopathy. Research questions focused on…Usefulness of combined examination using Frontal Assessment Battery (FAB) and Single Photon Emission Computer Tomography in the differentiation of 4 repeats (4R) tauopathic atypical parkinsonism
Objective: The aim of the work is to analyze whether combined examination of the frontal lobe using single photon emission computer tomography (SPECT) and Frontal…ARISE study: Study Design and Baseline Characteristics for a Phase 2 Trial of the Anti-Tau Antibody ABBV-8E12 in Progressive Supranuclear Palsy
Objective: This double-blind, placebo-controlled phase 2 study (M15-562 ARISE study, NCT02985879) assesses the safety and efficacy of ABBV-8E12 treatment in patients with progressive supranuclear palsy…Striatal FP-CIT SPECT findings for progressive supranuclear palsy subtypes
Objective: In our previous study FP-CIT SPECT (FP-CIT) in progressive supranuclear palsy-Parkinsonism (PSP-P) revealed higher anterior striatal accumulation, and PSP- Richardson’s syndrome (PSP-RS) revealed lower…Motor and cognitive deficits in a mouse model of tauopathy with tau isoforms imbalance: Potential therapeutic strategies
Objective: This work investigates motor phenotypes and neurochemical changes in a mouse model of tauopathy linked to tau mis-splicing. We sought to validate a potential…An atutopsy case of argyrophilic grain disease, clinically presenting with Parkinson dementia
Objective: We here reported argyrophilic grain disases (AGD) with clinical diagnosis of Parkinson dementia. Background: AGD is a four-repeat tauopathy and its accumulation (argyrophilic grain…Analysis of Tau Burden and Distribution on the Spectrum of PSP Subtypes
Objective: The aim of this study was to assess the previous hypothesis about relationship between clinical spectrum of Progressive Supranuclear Palsy (PSP) and tau burden…
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