MAPT mutation frontotemporal dementia with parkinsonism: when previous results can skew the diagnosis
Objective: Case report presentation. Background: In frontotemporal dementia with parkinsonism (FTDP), several mutations in MAPT gene have been identified, and numerous family cases were reported,…Long and short survival in Parkinson syndrome: pathology and genetics are key prognostic factors
Objective: To study the clinical, pathological and genetic profile of Parkinson syndrome (PS) cases that have > 20 years survival (long survival, or LS) compared…No frank biochemical evidence of proteinopathy in the cerebellar cortex of patients with essential tremor
Objective: This study was designed to determine the presence of common types of proteinopathies in the cerebellar cortex of patients who died with essential tremor…TAU pathology contributes to specific patterns of structural brain damage and neuropsychological heterogeneity in Huntington’s disease
Objective: Explore the associations between CSF levels of neurofilament light chain (Nfl), total TAU (tTAU) and phosphorylated TAU (pTAU), structural brain damage and cognitive performance…Tau Neuropathology Associates with In Vivo Patterns of Neurodegeneration in Lewy Body Disorders
Objective: Investigate the impact of Alzheimer’s disease (AD) co-pathology on an in vivo structural measure of neurodegeneration in Lewy Body disorders (LBD: Parkinson’s Disease and…Identification and characterization of anti-prionic compounds that disassemble Tau prions as a novel therapeutic approach for tauopathies
Objective: Stabilization of monomeric Tau protein by transient and high-affinity binding ligands is a novel and highly innovative anti-prionic treatment strategy for tauopathies. Background: Tauopathies…Mixed pathologies in pancreatic beta-cells from subjects with neurodegenerative diseases and their interaction with prion protein
Objective: We studied whether, as in the brain, pancreatic -cells of subjects with neurodegenerative diseases also present co-occurrence of other misfolded proteins. Furthermore, we also assessed…Clinical features and natural course of corticobasal degeneration and progressive supranuclear palsy presenting as corticobasal syndrome
Objective: To compare clinical features and natural course of corticobasal degeneration (CBD) presenting as corticobasal syndrome (CBD-CBS) and progressive supranuclear palsy presenting as corticobasal syndrome…Cognitive Differences Between Men and Women with Progressive Supranuclear Palsy
Objective: (1) To evaluate the cognitive differences between men and women with progressive supranuclear palsy (PSP) and (2) to investigate whether sex has an effect…The severity and distribution of tau pathology distinguish corticobasal degeneration and progressive supranuclear palsy
Objective: To elucidate whether the severity and distribution of tau pathology reflect the clinical presentations in progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD). Background:…
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