Sex comparisons for co-pathologies and clinical phenotypes in autopsy-confirmed four-repeat tauopathies
Objective: To assess whether co-pathologies and clinical phenotypes in people with four-repeat tauopathies (progressive supranuclear palsy [PSP], corticobasal degeneration [CBD]) differ by sex. Background: PSP…TMEM106B Amyloid Fibrils in the Choroid Plexus Mediate [18F]AV-1451 Retention: Cohort-Level Imaging and Cryo-EM Evidence
Objective: To determine whether TMEM106B fibrils contribute to AV-1451 retention in the choroid plexus (CP) and to elucidate the structural basis of their binding. Background:…GBA1 deficiency promotes tau and TDP-43 co-pathology
Objective: To determine whether mutations in the gene beta-glucocerebrosidase 1 (GBA1), the strongest genetic risk factor for PD, promote tau and TDP-43 co-pathology alongside Lewy…Emerging Roles for Imaging Techniques in Differentiating Underlying Pathologies in Corticobasal Syndrome
Objective: This review evaluates limitations in differentiating underlying pathologies in Corticobasal syndrome (CBS). We summarize available evidence on clinical features, imaging and fluid biomarkers and…Paired cerebrospinal fluid and serum analysis of irisin and associated LC3B levels in Parkinson’s disease and atypical Parkinsonism
Objective: The objective of the study is to investigate potential group differences in irisin and LC3B levels in paired cerebrospinal fluid (CSF) and serum samples…An Elevation in the Serum Biomarker pTau-181 May Identify Progressive Supranuclear Palsy Pathology
Objective: To report three cases of progressive supranuclear palsy (PSP) with significantly elevated pTau-181 levels on serum testing. Background: According to the MDS-endorsed PSP Study…Identification of Alpha-synuclein Pathology in Primary Tauopathies by Seed Amplification Assay
Objective: To assess intravitam frequency and type of misfolded α-synuclein aggregates (syn-seeds) in participants with clinically defined primary tauopathies, such as progressive supranuclear palsy (PSP)…Exploring the Genetic Landscape of Corticobasal Syndrome in Asian Populations
Objective: We aimed to investigate the genetic spectrum of corticobasal syndrome (CBS) in a sizable Asian cohort. Background: CBS is a rare, rapidly progressive neurodegenerative…Plasma Phospho-Tau217 and Neuromelanin-Sensitive MRI as Candidate Biomarkers in Beta-Propeller Protein-Associated Neurodegeneration
Objective: To evaluate plasma phosphorylated tau at threonine 217 (pTau217) and neuromelanin-sensitive MRI (NM-MRI) as candidate biomarkers reflecting tau pathology and nigral iron deposition in…Disease Characteristics of the First 100 Participants in the CurePSP Genetics Program Cohort
Objective: To increase our understanding of the pathogenesis of atypical parkinsonian disorders though genetics, and to build a cohort of individuals for future research. Background:…
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