Amyloid status differentiates synaptic loss and atrophy in Corticobasal Syndrome.
Objective: In this observational/cross-sectional study, we tested whether the degree and extent of in vivo synaptic loss differed in patients with corticobasal syndrome according to…CBS presenting rapidly progressive anterior operculum syndrome with suggested background pathology of 4-repeat tauopathy by tau PET: A case report
Objective: Report of a case with suspected TDP-43 proteinopathy as the pathological background in the early stage of the disease, and a final diagnosis of…Introducing the molecular subtyping of Progressive Supranuclear Palsy: a proof of concept
Objective: To enhance understanding of the molecular mechanisms underlying disease heterogeneity in Progressive supranuclear palsy (PSP) Background: PSP is a 4R-tauopathy characterised by subcortical pathology…Transferrin as a possible CSF biomarker in neurodegenerative proteinopathies
Objective: The aim of this study was to determine whether cerebrospinal fluid (CSF) levels of transferrin differ between patients with Parkinson´s disease (PD), multiple system…Phenotypic characterization of 104 patients with Progressive Supranuclear Palsy: A Tertiary care experience from South India
Objective: To prospectively evaluate and subtype the patients of Progressive supranuclear palsy being referred to a tertiary care movement disorders facility in South India. Background:…Early-onset cortico-basal degeneration (CBD) due to a c.2092G>A MAPT mutation
Objective: To describe a patient with early-onset atypical parkinsonism that evolved to a classic CBD without dementia, associated to a c.2092G>A MAPT mutation Background: Although…Cell-specific MAPT gene expression is preserved in tau cytopathologies in Progressive Supranuclear Palsy
Objective: To systematically map and quantify MAPT expression in neurons, astrocytes and oligodendroglia across different brain regions to determine whether cell type and/or regional differences…Structural analysis of the basal ganglia using ex vivo 7T MRI can differentiate frontotemporal lobar degeneration with TDP-43 vs tau accumulation.
Objective: Ex vivo 7T MRI can identify macrostructural changes in the basal ganglia that reflect underlying neuropathology, and can be used to differentiate between proteinopathies…18f-PI-2620 tau PET neuroimaging, tau protein burden and 18f-PI-2620 tau autoradiography on human postmortem brain tissue in a PSP patient
Objective: Our aim is to describe the findings of 18F-PI-2620 tau-PET imaging, together with tau protein burden and 18F-PI-2620 tau autoradiography in brain tissue from…Clinico-pathological correlations in atypical parkinsonism
Objective: We aim to assess diagnostic accuracy of the Parkinson-plus syndromes (PPS) using the current consensus criteria, whilst identifying the diagnostically most salient clinical features.…
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