Suvecaltamide Metabolites Are CaV3 Modulators and Contribute to Pharmacological Effect
Objective: To determine the potency-concentration relationships and combined pharmacological effects for suvecaltamide and its 2 active metabolites (JZZ05000034=M01, JZZ05000035=M02; total active moiety [TAM]). Background: T-type…SAGE-324/BIIB124, an investigational GABAA receptor PAM, for treatment of essential tremor
Objective: KINETIC2 is a multicenter, randomized, placebo-controlled, dose-response Ph2b study evaluating SAGE-324/BIIB124 for treatment of essential tremor (ET). Background: ET is a common movement disorder1,2…Contribution to Efficacy by Active Metabolites of Suvecaltamide in a Preclinical Rat Model of Essential Tremor
Objective: Present the pharmacokinetic/pharmacodynamic (PK/PD) relationship and contribution to anti-tremor efficacy for suvecaltamide and its active metabolites (JZZ05000034=M01, JZZ05000035=M02) in a harmaline-induced rat model of…Once-Daily Suvecaltamide Pharmacokinetics, Safety, & Tolerability–Phase 1, Randomized, Double-Blind, Multiple Ascending Dose Study
Objective: Evaluate the pharmacokinetics (PK), safety, and tolerability of a once-daily (QD) suvecaltamide (JZP385) formulation and its major active metabolites (JZZ05000034=M01, JZZ05000035=M02) in a Phase…The Fazekas scale score and the occurrence of adverse events after MRgFUS thalamotomy, is there a relationship?
Objective: To analyse whether the score on the Fazekas scale (FS) correlates with an increased risk of adverse effects (AEs) after unilateral magnetic resonance-guided focused…Outcomes of Focused Ultrasound Thalamotomy in Tremor Syndromes
Objective: To report on the outcomes between tremor subtypes, Essential Tremor (ET), Dystonic Tremor (DT) and Parkinson Disease Tremor (PDT), following a unilateral Magnetic Resonance…The added value of accelerometric monitoring during thalamotomy
Objective: To quantify the clinical changes in tremor during the different stages of thalamotomy, and to investigate the relationship between intraoperative findings and clinical outcome.…The feasibility of MRI guided focused ultrasound for posttraumatic tremor with prior hemicraniotomy and skull defect
Objective: To assess the feasibility of MRgFUS lesioning in the context of prior hemicraniotomy Background: Targeted stereotactic lesioning, using MRgFUS, is an effective treatment option…Improved Tremor Response to Focused Ultrasound Thalamotomy
Objective: This study sought to determine if, when using four tract tractography (FTT) to target the decussating and non-decussating dentatorubrothalamic tracts (DRTTs), essential tremor (ET)…Anti-tremor efficacy of Nabiximols (JZP378) in a rat Model of essential tremor
Objective: To assess the effect of acute and subchronic oral administration of nabiximols (JZP378), a complex botanical cannabinoid drug mixture with Δ9-tetrahydrocannabinol (THC) and cannabidiol…
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