Session Time: 1:45pm-3:15pm
Location: Exhibit Hall C
Objective: To describe clinical and imaging biomarkers of nonmotor symptoms burden (NMSB) as defined by NMS questionnaire (NMSQ) scores in a prospective international cohort study of Parkinson’s disease (PD).
Background: NMS are integral to PD and NMSB grading is now validated using NMSQ (1). Relationship of self-declared NMSB with objective biomarkers of PD has not been studied before.
Methods: 179 patients (68.5±11.4 yrs) have been studied (disease duration 7.29±6,85 yrs, 7% drug-naive, median Hoehn Yahr (HY) 2). Measures of motor state, sleep, depression, anxiety, quality of life (QoL), Datscan and olfaction were collected.
Results: 17% were NMSB mild, 30% moderate, 26% severe, 26% very severe. 12% had very severe and 16% severe NMSB inspite of mild HY. Motor dysfunction was worse in very severe NMSB. Significant deterioration was seen with anxiety (mild 6.1 vs very severe 11) and QoL (mild 5.1 vs very severe 16). PD sleep scale total score worsened significantly with increasing NMSB. Datscan putamen uptake ratios were non-significant between NMSB (Table 1) in contrast to HY (Figure 1). Olfaction was significantly worse in very severe (70%) vs severe (32%), moderate (17%) and mild (13%).
Conclusions: Self-declared NMSB grading is capable of identifying subgroups of NMS dominant phenotypes. Very severe NMSB is characterised by olfactory, sleep and anxiety disorders but relatively retained putaminal dopamine transporter uptake.
References: Chaudhuri KR, Sauerbier A, Rojo JM, Sethi K, Schapira AH, Brown RG, Antonini A, Stocchi F, Odin P, Bhattacharya K, Tsuboi Y, Abe K, Rizos A, Rodriguez-Blazquez C, Martinez-Martin P. The burden of non-motor symptoms in Parkinson’s disease using a self-completed non-motor questionnaire: a simple grading system. Parkinsonism Relat Disord. 2015 Mar;21(3):287-91. doi: 10.1016/j.parkreldis.2014.12.031.
To cite this abstract in AMA style:N. Titova, S. Cankaya, F. Spinnato, E. Katunina, P. Martinez-Martin, M. Qamar, K.R. Chaudhuri. Self-rated burden grading of nonmotor symptoms identifies landmarks and subtypes of Parkinson’s disease: first report from a Moscow-Madrid-London collaboration [abstract]. Mov Disord. 2017; 32 (suppl 2). http://www.mdsabstracts.org/abstract/self-rated-burden-grading-of-nonmotor-symptoms-identifies-landmarks-and-subtypes-of-parkinsons-disease-first-report-from-a-moscow-madrid-london-collaboration/. Accessed February 18, 2018.
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MDS Abstracts - http://www.mdsabstracts.org/abstract/self-rated-burden-grading-of-nonmotor-symptoms-identifies-landmarks-and-subtypes-of-parkinsons-disease-first-report-from-a-moscow-madrid-london-collaboration/