Natural history and disease progression biomarkers of multiple system atrophy: the ASPIRE-MSA study
Objective: To evaluate multiple system atrophy (MSA) disease progression on a panel of candidate MSA biomarkers pre-selected for their putative involvement in the pathophysiology of…Signs of Respiratory Dysfunction across Parkinson’s Disease Spectrum
Objective: The aim of the study is to investigate signs of respiratory dysfunction across the Parkinson’s disease spectrum. Background: Respiratory dysfunction in Parkinson’s disease (PD)…Actigraphy wear compliance across CNS disorders
Objective: Examine actigraphy wear compliance in 5 neurological-disorders clinical trials using an ActiGraph GT9X Link with additional compliance features Background: Wrist worn biometric devices are…Multimodal Conversational AI for Remote Patient Monitoring and Analysis of Parkinson’s Disease
Objective: To present, analyze and evaluate a cloud-based audio-visual dialog agent and its associated automated speech, face and movement analytics for remote patient monitoring in…Alpha-synuclein and Amyloid beta peptide 1-42 in Parkinson’s disease and parkinsonian plus syndrome cohorts
Objective: To evaluate the serum levels of α-synuclein (α-syn) and Amyloid β 1-42 (Aβ1-42) in the patients of Parkinson’s disease (PD), progressive supranuclear palsy (PSP)…Parkinson Kinetigraph – does it change the management of PD patients?
Objective: This pragmatic randomized open trial evaluated if the information from a Parkinson Kinetigraph (PKG) recording changed the management of PD patients at a visit…Motor assessments in HD clinical trials: Q-Motor versus the UHDRS-TMS – what did we learn from recent studies?
Objective: To review the performance of UHDRS-TMS and Q-Motor quantitative motor measures in recent placebo-controlled clinical trials. Background: The UHDRS-TMS has widely been used to…Alignment of objective markers of speech with listener based judgements and disease severity in Friedreich ataxia
Objective: To identify a subset of acoustic markers of speech that objectively describe listener perceptions, disease severity and speech related quality of life in Friedreich…Preliminary validation of a novel, comprehensive digital biomarker smartphone application to assess motor symptoms in de-novo diagnosed Parkinson patients
Objective: To determine the reliability and validity of a novel, comprehensive digital biomarker remote monitoring approach to actively and passively measure motor symptom progression in…Stability and reliability of objective measures of speech in Parkinson’s Disease over 12 months
Objective: To describe the stability and reliability of acoustic measures of speech in Parkinson’s Disease (PD) at 3 and 12 months. Background: Speech biomarkers hold…