Session Information
Date: Wednesday, June 22, 2016
Session Title: Ataxia
Session Time: 12:00pm-1:30pm
Location: Exhibit Hall located in Hall B, Level 2
Objective: In Early Onset Ataxia (EOA), we investigated whether quantitative analysis employing motion sensors could provide reliable and discriminative outcomes.
Background: Many pediatric conditions can affect coordination, including EOA, developmental coordination disorder (DCD) and physiologically immature coordination by age. For clinical surveillance and treatment evaluation, uniform phenotypic distinction between underlying conditions is important, but complicated.
Methods: We included 32 children with different phenotypic causes for coordination impairment, involving ataxia (n=9; 13.3 ± 3.8 y), DCD (n=7; 9.4 ± 2.1 y) and healthy age-related controls (n=16; 11.9 ± 3.3 y). All children performed the “finger-to-nose” SARA sub-test with three attached inertial measurement units, providing information on the index finger position according to a 3D upper limb model. We used quantitative movement features of the movement to classify each child as ataxic, DCD or healthy.
Results: None of the children quantitatively classified as EOA were phenotyped as control; 5% classified as control were phenotyped as ataxic; 22% classified as EOA were phenotyped as DCD and 26% classified as DCD were phenotyped as ataxic. The overall agreement between quantitative classification and phenotypic assessment was 78% for ataxia, 83% for controls and 31% for DCD.
Conclusions: Finger-to-Nose” test outcomes provided excellent discrimination between EOA and controls, and reasonable discrimination between EOA and DCD. As a golden standard for phenotypic DCD assessment is lacking, it remains elusive whether quantitative classification or phenotypic diagnosis was more inaccurate. In EOA, future additional quantitative gait analysis may provide a reliable and discriminative biomarker for total EOA assessment.
This abstract will be presented at the 14th International Child Neurology Congress in Amsterdam, the Netherlands in May 2016.
To cite this abstract in AMA style:
O.E. Martinez Manzanera, T. Lawerman, D.A. Sival, N. Maurits. Can quantitative analysis of the “finger-to-nose test” discern between EOA and other conditions of coordination impairment? [abstract]. Mov Disord. 2016; 31 (suppl 2). https://www.mdsabstracts.org/abstract/can-quantitative-analysis-of-the-finger-to-nose-test-discern-between-eoa-and-other-conditions-of-coordination-impairment/. Accessed June 15, 2025.« Back to 2016 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/can-quantitative-analysis-of-the-finger-to-nose-test-discern-between-eoa-and-other-conditions-of-coordination-impairment/