Session Information
Date: Monday, June 5, 2017
Session Title: Parkinson's Disease: Non-Motor Symptoms
Session Time: 1:45pm-3:15pm
Location: Exhibit Hall C
Objective: To explore the association between metabolic syndrome and Unified Parkinson Disease Rating Scale (UPDRS) scores.
Background: While studies suggest that metabolic syndrome increases the risk of Parkinson disease (PD), it is not known if it is associated with the rate of progression.
Methods: This is a secondary analysis of data from 1022 out of 1741 participants of the NINDS Exploratory Trials in PD Long-term Study 1, a randomized, double-blind, placebo-controlled trial of the effect of 10 mg creatine on progression of PD. Participants were within 5 years of diagnosis of PD and were on dopaminergic therapy at the time of study entry. They were categorized as having or not having metabolic syndrome based upon modified criteria from the National Cholesterol Education Program Adult Treatment Panel III. Only those without missing data and that had the same metabolic syndrome status at consecutive annual visits were included. The change in total and motor UPDRS scores from randomization to three years was compared in participants with metabolic syndrome to those without metabolic syndrome.
Results: Participants with metabolic syndrome, n=396, compared to those without, n=626, were older (mean [SD] 63.9 [8.1] years vs. 59.9 [9.4] years; p<0.0001), more likely to be male (75.3% vs. 57.0%; p<0.0001) and had a higher mean uric acid level (men 5.7 [1.3] vs. 5.3 [1.1], women 4.9 [1.3] vs. 3.9 [0.9]; p<0.0001). Participants with metabolic syndrome experienced an additional 0.6 [0.2] unit annual increase in total UPDRS (p=0.02) and 0.5 [0.2] in motor UPDRS (p=0.004) scores compared with non-metabolic syndrome participants even after adjusting for the above covariates.
Conclusions: Persons with PD meeting modified criteria for metabolic syndrome experienced a greater increase in total UPDRS scores over time, mainly due to increases in motor scores, compared to those who did not. Further studies are needed to confirm this finding.
To cite this abstract in AMA style:
M. Leehey, S. Luo, S. Sharma, A.-M. Wills, J. Bainbridge, D. Simon, J. Schneider, Y. Zhang, A. Pérez, R. Dhall, C. Christine, C. Singer, F. Cambi. Association of Metabolic Syndrome and Change in Unified Parkinson Disease Rating Scale Scores [abstract]. Mov Disord. 2017; 32 (suppl 2). https://www.mdsabstracts.org/abstract/association-of-metabolic-syndrome-and-change-in-unified-parkinson-disease-rating-scale-scores/. Accessed June 15, 2025.« Back to 2017 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/association-of-metabolic-syndrome-and-change-in-unified-parkinson-disease-rating-scale-scores/