Session Information
Date: Monday, October 8, 2018
Session Title: Parkinson's Disease: Non-Motor Symptoms
Session Time: 1:15pm-2:45pm
Location: Hall 3FG
Objective: To determine the frequency of dysautomic disorders and structural cardiac abnormalities in patients with early PD.
Background: Parkinson´s disease (PD) is a neurodegenerative disease characterized by motor and non-motor symptoms. Among the later, disorders of the autonomic nervous system such as orthostatic hypotension (OH) are common. Other autonomic abnormalities (AA) such as nocturnal hypertension (NH) and the loss of nocturnal blood pressure dipping (LNBPD) have been associated to other cardiovascular abnormalities (CA) and mortality. The most common CA are left ventricular hypertrophy (LVH), cardiac ischemia, heart failure and arrhythmias.
Methods: A cross-sectional study was carried out. Twenty patients with early PD (<5 years) were included. A structured questionnaire was applied. MDS-UPDRS part 3 and Höehn and Yahr were aplied. Autonomic testing included table tilt test, Valsalva index, and OH assessment. Cardiac evaluation included echocardiogram. In addition, a 24-hour ambulatory blood pressure monitoring was performed.
Results: A total of 11 males and 9 females were included. The mean age was 61.4±6.1 and a disease duration of 4.2±0.9 The mean MDS-UPDRS part 3 was 17±9. LVH was found in 5 patients, NH in 11 patients, and LNBPD in 13 patients. On the other hand, heart variability was abnormalin all cases. OH was found in 12 cases. In most cases, no corresponding symptoms were reported.
Conclusions: Both cardiac and dysautonomic disturbances are frequent in early PD patients; although mostly subclinical; it is therefore important to look for these disroders through proper testing in order to impact their quality of life and morbi- mortality.
References: 1.- Goldstein DS. Orthostatic hypotension as an early finding in Parkinson disease. Clin Auton Res 2006;16:46–64. 2.- Goldstein DS, Holmes C, Li ST, Bruce S, Metman LV, Cannon III RO. Cardiac sympathetic denervation in Parkinson disease. Ann Intern Med Sep 5 2000;133 (5):338–47.
To cite this abstract in AMA style:
J. Balderas, A. Gonzalez. “Frequency of autonomic and cardiovascular abnormalities in Mexican patients with early Parkinson’s disease” [abstract]. Mov Disord. 2018; 33 (suppl 2). https://www.mdsabstracts.org/abstract/frequency-of-autonomic-and-cardiovascular-abnormalities-in-mexican-patients-with-early-parkinsons-disease/. Accessed June 15, 2025.« Back to 2018 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/frequency-of-autonomic-and-cardiovascular-abnormalities-in-mexican-patients-with-early-parkinsons-disease/