Session Information
Date: Wednesday, June 22, 2016
Session Title: Phenomenology and clinical assessment of movement disorders
Session Time: 12:00pm-1:30pm
Location: Exhibit Hall located in Hall B, Level 2
Objective: To report (1) the relationship between the occurrence of impulse control disorders (ICDs) and dyskinesias, and (2) the correlations between specific ICDs and the presence of dyskinesias, in advanced Parkinson’s disease (PD) patients.
Background: ICDs in PD are a common and disabling complication of dopaminergic treatment. It has been suggested that the presence of dyskinesia may be associated with greater risk and severity of ICD.
Methods: The ALTHEA multicenter study enrolled 232 advanced PD patients who underwent a comprehensive assessment which included the Unified Dyskinesia Rating Scale (UDysRS), the Unified Parkinson’s disease Rating Scale (UPDRS) and the Questionnaire for Impulsive Compulsive Disorders in Parkinson’s disease – Rating-Scale (QUIP-RS). We applied published QUIP-RS cut-off values for each ICD to separate between clinically significant ICD and mild symptoms.
Results: Out of the 232 patients tested, 138 had ICDs. Their mean age was 64 (27-84) years, and the mean disease duration was 140 (36-396) months. 69 patients had Quip-RS scores above the cut off values and were younger at disease diagnosis than the 94 patients without ICDs, with median ages of 52(34-70) and 58(17-80) years, respectively (p=0.004). The median UDysRS total scores, in the groups of patients without ICDs and those with QUIP-RS scores above the cut-off values, were 22(1-79) and 31(0-78), respectively (p=0.001). There was no overall correlation between dyskinesia severity and total QUIP-RS score. However, in the subgroup presenting with single ICDs (N=35), there was a strong trend for a positive correlation between hobbyism and dyskinesia severity (r=0.34; N=28; p=0.06), while punding had a negative correlation (r =-0.35; N=28; p=0.05).
Conclusions: Dyskinesia did not correlate with ICD severity, as expressed by the QUIP-RS total score, in the analyzed group, but individual ICDs manifested different correlation tendencies with dyskinesia severity.
XXI World Congress on Parkinson’s disease and Related Disorders, 6-9 December, Milan, Italy.
To cite this abstract in AMA style:
R.J. Vorovenci, L. Weis, R. Biundo, A. Antonini. The relationship between impulse control disorders and dyskinesia in Parkinson´s disease: The ALTHEA study [abstract]. Mov Disord. 2016; 31 (suppl 2). https://www.mdsabstracts.org/abstract/the-relationship-between-impulse-control-disorders-and-dyskinesia-in-parkinsons-disease-the-althea-study/. Accessed June 14, 2025.« Back to 2016 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/the-relationship-between-impulse-control-disorders-and-dyskinesia-in-parkinsons-disease-the-althea-study/