Objective: 1.To identify the representation and prevalence of non-motor symptoms of PD in the premotor and early motor stages

Background: During the period 2016-2018 104 people were examined: 63 patients with the first diagnosis of PD, not treated earlier, and 41 people in the control group.

Method: The following scales were used:- The scale of the UPDRS part III – Questionnaire “Mini-study of mental state” (MMSE)-Rating scale of sleepiness “SCOPA-SLEEP” – Hamilton scale for assessing depression -Scale Hyun and Yar

Results: When comparing non-motor manifestations depending on the form of the disease, we have identified the following most significant symptoms:- Salivation was observed in 20% of patients with a tremulous form of the disease, 26.1% of patients with a rigid form of the disease ( p=0.046).Change or loss of smell and taste was observed in 20% of patients with tremulous form of the disease, 34.8% of patients with rigid form of the disease ( p=0.008). Change in the weight of the unknown cause was observed in 35.1 % of patients with the tremulous form of the disease, 39.1 % of patients with the rigid form of the disease ( p=0.009). Constipation was observed in 54.5% of patients with tremulous form of the disease, 43.5 % of patients with rigid form of the disease ( p=0.010).- Visual and auditory hallucinations were observed in 20% of patients with a tremulous form of the disease, 34.5 % of patients with a rigid form of the disease( p=0.002).- Discomfort at night in the legs was observed in 50% of patients with tremulous form of the disease, 39.1 % of patients with rigid form of the disease( p=0.007). When comparing the control group and patients with Parkinson’s disease, we saw that the following non-motor manifestations were significantly more frequent.

Conclusion: The analysis showed that these non-motor symptoms at UPDRS school in patients with Parkinson’s disease were significantly more pronounced compared to the control group. Despite the fact that non-motor manifestations of PD are not specific, it is worth paying attention to the combination of more than 10 different non-motor symptoms in patients, which is impossible with natural aging. It is important to remember that early diagnosis of PD increases the patient’s chance for a favorable course of PD by selecting a competent pharmacotherapy.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/non-motor-symptoms-parkinsons-disease/