Objective: to study the association between helicobacteriosis pylori (HP) and patients with Parkinson’s disease

Background: Helicobacter pylori is a bacterium associated with gastrointestinal diseases and It was stated that HP might lead to the pathogenesis of PD by causing direct damage to the dopaminergic neurons or acting as neurotoxins via increasing the level of cholesterol glucosides. In addition, HP can increase the level of proinflammatory mediators induced by peripheral inflammatory, which can cross blood brain barriers and subsequently trigger neurodegeneration.

Method: We prospectively recruited 39 PD patients from November 2020 to December 2021. All patients underwent a detailed neurological evaluation and urea breath test for H. pylori infection. Positive and negative patients were considered to be the cases and controls, respectively.

Results: We have found that 38.5% of 39 PD patients were infected with HP. These infected PD patients were older (age, 67.4±4.98 years). Compared to HP-negative patients, HP-positive patients had a statistically significantly worse score according to the UPDRS (34.0±13.0 vs. 27.3±10.0, p=0.04); That study revealed important effects of HP infection on UPDRS-III of PD patients; it was found that HP status and its relationship with these motor results varied according to age.

Conclusion: The prevalence of HP infection among PD patients is significantly higher and is more common in patients over 60 years of age. The relationship between HP and PD should be further clarified by more-comprehensive studies in the future.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/the-prevalence-of-helicobacter-pylori-in-parkinsons-disease/