Objective: To investigate the temporal dynamics of striatal binding ratios (SBRs) among individuals with Parkinson’s disease (PD)-related mutations and its’ association with likelihood ratio (LR) for prodromal PD.  

Background: Dopamine transporter spectral positron emission computed tomography (DaTscan) is widely used for establishing PD diagnosis and receives high importance in LR scores estimation. However, the association between DaTscan measures and LR scores over time remains unclear.

Method: 52 healthy first-degree relatives (age 52.73±8.72 yrs, 22/30 F/M) were enrolled. All participants were genotyped and underwent DaTscan at baseline and on average after 2.21±0.3 years, and a comprehensive clinical assessment battery. LR scores and striatal binding ratio (SBRs) were calculated for all included participants. The relationship between DaTscan-derived measures and LR scores was investigated using hierarchical regression models accounting for age and sex.

Results: N=14 GBA Non-Manifesting Carriers (NMC), N= 14 LRRK2 NMC, and N=24 age-matched Non-Manifesting Non-Carriers (NMNC) were included in each study group. No significant differences were detected in clinical measures and rates of change (ROC) in striatal SBRs among the study groups. Over time LR difference were associated with right putamen SBR, putamen asymmetry index, right putamen-caudate ratio at baseline (R ²= 0.11 p=0.035; R ²= 0.17 p=0.007; R ²= 0.16 p=0.009 respectively), and with SBR ROC in the right caudate (R ²=0.1 p=0.036).

Conclusion: DaTscan-derived asymmetry metrics might serve as an early marker for LR increase over time, reflecting subclinical changes preceding symptoms onset in the prodromal phase of PD.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/datscan-striatal-binding-ratio-dynamics-in-mutations-carriers-at-risk-for-parkinsons-disease-a-2-year-prospective-study/