Category: Parkinson's Disease: Cognitive functions
Objective: To identify motor, cognitive and overall ICDs differences by sex in Mexican patients with PD and ICDs
Background: ICDs are characterized by a failure to resist impulses to perform activities that are harmful to the person or to others, due to their excessive nature. Patients with PD have a higher risk of presenting these conditions. Studies that consider sex as a crucial variable are underrepresented in PD research internationally. Few are the studies carried out in Mexico and Latin America on the ICDs and even fewer consider gender as an important variable in their design.
Method: Observational, analytical, cross-sectional study, where the QUIPRS scale was applied to 555 patients with PD, as well as MOCA and MDS-UPDRS. The patients were evaluated in the clinic of abnormal movements in the National Institute of Neurology and Neurosurgery “Manuel Velasco Suárez” in a period of 4 years.
Results: We included 555 patients: Men (55.5%) women (44.5%) with an average age of 63.02 ± 12.8. Within our group of patients, we observed 57 (10.3%) with ICDs within these 37 men (64.9%) and 20 women (35.1%) with the following characteristics:
MOCA: W (Mean score= 23.3); M (Mean score= 21.8); (P= 0.48)
QUIP-RS: W (Mean score= 17.65); M (Mean score= 14.19); (P = 0.06)
UPDRS1: W (Mean score= 12.21); M (Mean score= 13.86); (P = 0.47)
UPDRS2: W (Mean score= 9.63); M (Mean score= 13.35); (P = 0.99)
UPDRS3: W (Mean score= 31.55); M (Mean score= 31.78); (P = 0.51)
UPDRS4: W (Mean score= 4.10); M (Mean score= 3.27); (P = 0.86)
Conclusion: We were able to observe a lower prevalence of ICD in our population compared to studies previously conducted in Mexico, we did not find significant differences of the MDS-UPDRS or MOCA ratings comparing men and women with ICD, however we did observe a trend towards higher QUIP-RS global scores in women despite not being significant (P= 0.06). These results may indicate a greater severity in women with Parkinson’s and ICD in the Mexican population. We believe that increasing the sample size would help us to increase the level of confidence. Carrying out more studies that take into account the differences between the sexes can lead to generating interventions for the different needs of men and women with PD with ICDs.
References: 1. Mayela RV, Paulina GL, Amin CA, et al. Impulse control and related disorders in Mexican Parkinson’s disease patients. Parkreldis. 2014; 20(8): 907-10.
2. Silvia C, Liudmila M, Fabio B. Parkinson`s Disease in Woman and Men: Whats the Difference?. J Parkinsons Dis. 2019; 9(3) 501-515.
To cite this abstract in AMA style:
A. Alcocer-Salas, M. Rodriguez-Violante, A. Cervantes-Arriaga, J. García-Hernández, A. Abundes-Corona, A. Hernández-Medrano, D. Aguila-Godinez, A. Herrera-Ruiz, E. Santiago-Delacruz, L. Lira-Juárez, M. Medrano-Delgado, M. Ruiz-Mafud, A. Regalado-Mustafá, D. Romero-Terán, M. Medina-Pérez, G. Hernandez-Armesto, A. Domínguez-García. Differences by sex in patients with Parkinson’s disease (PD) and impulse control disorder (ICD) in the Mexican population. [abstract]. Mov Disord. 2023; 38 (suppl 1). https://www.mdsabstracts.org/abstract/differences-by-sex-in-patients-with-parkinsons-disease-pd-and-impulse-control-disorder-icd-in-the-mexican-population/. Accessed July 6, 2025.« Back to 2023 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/differences-by-sex-in-patients-with-parkinsons-disease-pd-and-impulse-control-disorder-icd-in-the-mexican-population/