Objective: This study is to investigate the neuroprotective effect of HSP in a mouse model of Parkinson’s disease (PD) caused by rotenone, with an emphasis on the effects of HSP on striatal angiogenesis and the transcription factor O3 pathway AMPK/FOXO3.
Background: In a verified model of Parkinson’s disease (PD), rotenone can cause complex I to be inhibited and microglia properties to be activated, which can result in oxidative stress, inflammation, neurotoxicity, and alterations in behavioral and locomotor functions. A diet rich in antioxidants has been linked to a decreased risk of neurodegenerative diseases, according to studies.
Method: In the ongoing study, mice were administered rotenone at repeated doses to induce Parkinson’s disease (PD). They were also given HSP at 100 or 200 mg/kg/day for eighteen days, and their performance on the rotarod and pole tests was evaluated. After being removed, the brains were ready for biochemical or immunohistochemical analyses. The angiogenic markers and oxidative stress indicators that were evaluated were malondialdehyde, reduced glutathione, hemoxygenase-1, vascular endothelial growth factor (VEGF), the nuclear factor erythroid 2?related factor 2 (Nrf2), thioredoxin, FOXO3, and AMPK.
Results: The findings showed that HSP enhanced the motor function, striatal glutathione, Nrf2, hemoxygenase-1, and thioredoxin of the mice. Moreover, MTF enhanced the number of striatal neuronal terminals and substantia nigra neurons that were labeled with tyrosine hydroxylase (TH). MTF also cleaved caspase 3 and decreased VEGF. This is the first study demonstrating that the AMPK-FOXO3 pathway and proangiogenic factor (VEGF) reduction are the mechanisms by which HSP mediates its neuroprotective effects.
Conclusion: Further study is required to evaluate the effect of HSP on Parkinson diseases process in further models of neurodegenerative disorders like Parkinson’s disease.
To cite this abstract in AMA style:
DS. Singh. Hesperidin lessens rotenone induced Parkinson diseases angiogenesis in nigrostriatal neuronal death through the AMPK/FOXO3 Signaling pathway [abstract]. Mov Disord. 2024; 39 (suppl 1). https://www.mdsabstracts.org/abstract/hesperidin-lessens-rotenone-induced-parkinson-diseases-angiogenesis-in-nigrostriatal-neuronal-death-through-the-ampk-foxo3-signaling-pathway/. Accessed May 9, 2025.« Back to 2024 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/hesperidin-lessens-rotenone-induced-parkinson-diseases-angiogenesis-in-nigrostriatal-neuronal-death-through-the-ampk-foxo3-signaling-pathway/