Objective: This review aimed to investigate the association between RBP levels and the risk of Parkinson’s disease
Background: RBP facilitates retinol transport from the liver to peripheral organs to meet vitamin A requirements. Previous studies suggest a link of pathophysiology of various neurological disorders to vitamin A-related compounds
Method: A comprehensive search of electronic databases was conducted from date of inception till 13th March 2024. Inclusion criteria encompassed human studies in English reporting RBP and Parkinson’s disease. Data were manually extracted into an Excel spreadsheet. Results were presented as standard mean deviations and 95% CI
Results: Preliminary analysis revealed that only 2 studies were eligible for the review. Serum RBP levels were measured in both the studies compared to controls. Overall analysis demonstrated no statistically significant difference between serum RBP levels in PD patients compared to controls suggesting no association between serum RBP levels and increased risk of PD
Conclusion: Our findings suggest that serum concentrations of RBP, do not play a role in the pathogenesis of PD. But since there are only two studies, we cannot comment on whether RBP play a role in PD by potentially influencing retinol transport and metabolism or not. However, further studies are needed to validate these findings and elucidate the underlying mechanisms linking RBP to risk of PD
References: 1. Jiménez-Jiménez FJ, Molina JA, Fernández-Calle P, Vázquez A, Pondal M, del Ser T, Gómez-Pastor A, Codoceo R. Serum levels of vitamin A in Parkinson’s disease. J Neurol Sci. 1992 Aug;111(1):73-6. doi: 10.1016/0022-510x(92)90114-z. PMID: 1403000.
2. Durrieu G, LLau ME, Rascol O, Senard JM, Rascol A, Montastruc JL. Parkinson’s disease and weight loss: a study with anthropometric and nutritional assessment. Clin Auton Res. 1992 Jun;2(3):153-7. doi: 10.1007/BF01818955. PMID: 1498561.
3. Zhao Y, Li C, Zhou X. Transcriptomic Analysis of Porcine Granulosa Cells Overexpressing Retinol Binding Protein 4. Genes (Basel). 2019 Aug 13;10(8):615. doi: 10.3390/genes10080615. PMID: 31412686; PMCID: PMC6722559.
To cite this abstract in AMA style:
V. Sharma. Association of Retinol Binding Protein (RBP) and the Risk of Parkinson’s disease (PD): A Narrative Literature Review [abstract]. Mov Disord. 2024; 39 (suppl 1). https://www.mdsabstracts.org/abstract/association-of-retinol-binding-protein-rbp-and-the-risk-of-parkinsons-disease-pd-a-narrative-literature-review/. Accessed June 15, 2025.« Back to 2024 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/association-of-retinol-binding-protein-rbp-and-the-risk-of-parkinsons-disease-pd-a-narrative-literature-review/