Objective: Primary: To assess QoL in PD patients at the Neurological Institute of Thailand (NIT).

Secondary: To identify clinical factors associated with QoL.

Background: Parkinson’s disease (PD) is a progressive neurodegenerative disorder that causes motor and non-motor symptoms, significantly affecting quality of life (QoL). However, comprehensive QoL assessments in Thailand remain limited.

Method: A cross-sectional study was conducted from October 1, 2024, to March 5, 2025. Data included demographics, disease duration, Hoehn and Yahr (HY) stage, motor and non-motor symptoms, levodopa equivalent daily dose (LEDD), and QoL assessed via PDQ-8. Disease severity was evaluated using the Movement Disorder Society-Unified Parkinson’s Disease Rating Scale (MDS-UPDRS). Spearman’s correlation and regression analyses identified QoL predictors.

Results: A total of 46 patients (mean age 59.24±8.54 years, 52.17% male, 45.65% urban residents) were included. Mean household income was 58,821.74±65,442.78 baht, and 52.17% had a bachelor’s degree or higher. The mean disease duration was 9.59±5.92 years, mean age at onset 49.65±9.11 years, and median HY stage 3.

Higher PDQ-8 scores, indicating poorer QoL, correlated with depression (r=0.52, p<0.01), urinary incontinence (r=0.38, p=0.02), and higher MDS-UPDRS scores: Part I (r=0.579, p<0.01), Part II (r=0.603, p<0.01), Part III (r=0.626, p<0.01), and Part IV (r=0.448, p=0.002).

Univariate regression identified depression (β=3.175, p=0.007), urinary incontinence (β=5.202, p=0.024), higher HY stage (β=1.208, p=0.045), and higher MDS-UPDRS scores (Part I: β=0.525, p<0.01; Part II: β=0.332, p<0.01; Part III: β=0.132, p=0.07; Part IV: β=0.517, p=0.001) as factors significantly associated with poorer QoL.

Multivariate regression found urinary incontinence (β=3.38, p=0.031), depression (β=2.16, p=0.01), MDS-UPDRS Part I (β=0.276, p=0.009), MDS-UPDRS Part III (β=0.063, p=0.018), and LEDD (β=0.0027, p=0.007) as independent predictors.

Conclusion: Motor and non-motor symptoms significantly impact the QoL of Thai PD patients. Urinary incontinence, depression, MDS-UPDRS Part I and III scores, and LEDD are independent predictors. These findings underscore the need for comprehensive, patient-centered management to improve disease control and QoL.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/quality-of-life-of-parkinsons-disease-patients-in-the-thai-population-a-cross-sectional-analysis/