Objective: To determine the role of cardiovascular risk factors such as diabetes, hypertension, obesity, dyslipidemia in the PD severity of motor and non motor symptoms, motor complications, dopaminergic treatment and LEDD.

Background: The cardiovascular risk factors and PD increase their incidence with aging. PD is one of the most common neurodegenerative diseases and cardiovascular risk factors are associated with neurodegeneration in the elderly causing dementia and worsening of PD symptoms.

Methods: Observational analytic study with consecutive patients with a PD diagnosis. A structured-interview was applied to all subjects. Weight, height, BMI, presence of comorbidities such as diabetes, hypertension, dyslipidemia was assessed as well as dopaminergic treatment, LEDD, HY, MDS-UPDRS and NMSS scales. Mann Whitney U test was used for non-parametric test.

Results: 500 consecutive patients (230 Female, 230 Male). The mean disease duration of 8.66±6.2 years. Mean LEDD was 748.3±444.35mg. The 76.8% of the patientes were treated with levodopa, 63.6% DA and 13.6% MAO-Bi. In the case of severity of disease mesured using the HY were as follows 57.8% HY I-II, 26.6% HY III and 15.6% IV-V. The mean scores in the MDS-UPDRS was 58.5±33.6 points, MDS-UPDRS III 29.67±18.5 points and global NMSS 63.4±49.7 points. In the case of cardiovascular risk factors 61% presented overweight, 36% diabetes, 21.8% dyslipidemia, 14.8% hypertension and 22.2% of the patients with no cardiovascular risk factors. The patients with diabetes had the highest NMSS global score (p=0.049) particularly in urinary symptoms domain (p=0.033) while having dyslipidemia were associated with lower LEDD (p=0.014) and higher MDS-UPDRS I subscale. The patients with lower BMI were related to higher scores in MDS-UPDRS II (p=0.041) and IV (p=0.007).

Conclusions: This study suggests that dyslipidemia is associated with lower LEDD, this is probably associated with dyslipidemia treatment. Diabetes was related with higher scores in the urinary domain posibly associated with the exacerbation in dysautonomia. The presence of higher scores in MDS-UPDRS part II and IV with lower BMI is probably related with drug induced motor complications associated with higher LEDD/Kg. There was no significant findings in PD patients with hypertension. These results are consistent with current literature.

XXXIX annual meeting of the Mexican Academy of Neurology.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/impact-of-cardiovascular-risk-factors-in-the-evolution-and-treatment-of-parkinsons-disease-in-mexican-population/