Objective: We evaluated the changes of insulin-like growth factor-1 bioavailability in the Parkinson’s disease patients after 28 day supplementation of blackcurrant anthocyanin.

Background: Elevated insulin-like growth factor-1 in plasma is a biomarker for Parkinson’s disease associated insulin-like growth factor-1 resistant. Berry rich diet may be associated with low risk of Parkinson’s disease. The ratio cyclic Glycine-Proline / insulin-like growth factor-1 determines the bioavailability of insulin-like growth factor-1.

Methods: Both plasma and cerebrospinal fluid samples were collected from 11 Parkinson’s disease patients before and after 28 days supplementation of black current extracts in an open label study. The concentration of insulin like growth factor-1, cyclic Glycine-Proline, insulin-like growth factor-, insulin-like growth factor binding protein 1-3 were measured using ELISA and High Performance Liquid Chromatography mass spectrometry assay.

Results: Blackcurrant anthocyanin supplementation increased cerebrospinal fluid cyclic Glycine-Proline concentration, which was correlated to plasma cyclic Glycine-Proline concentration and cyclic Glycine-Proline / insulin-like growth factor-1 ratio in plasma. In contrast, the supplementation did not alter the concentration of insulin-like growth factor-1 and insulin-like growth factor binding proteins in both plasma and cerebrospinal fluid.

Conclusions: The increase of cyclic Glycine-Proline in the cerebrospinal fluid may be the result of autocrine regulation of insulin-like growth factor-1 in the plasma increasing bioavailability and a positive response to insulin-like growth factor-1 resistance in Parkinson’s disease patients. Thus, the change of cyclic Glycine-Proline and ratio of cyclic Glycine-Proline / insulin-like growth factor-1 may be a biomarker for insulin-like growth factor-1 function in Parkinson’s disease, which needs to be further evaluated in a larger study.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/cyclic-glycine-proline-increased-in-the-cerebrospinal-fluid-of-parkinsons-patients-after-supplementation-of-blackcurrant-anthocyanins-potential-biomarker-for-treatment/