Session Information
Date: Monday, June 5, 2017
Session Title: Parkinson's Disease: Non-Motor Symptoms
Session Time: 1:45pm-3:15pm
Location: Exhibit Hall C
Objective: To evaluate the association between melatonin secretion rhythm and nocturnal polyuria, and the pathophysiology of nocturnal polyuria in PD.
Background: Patients with PD have not only motor impairment but also lower urinary tract dysfunction (LUTD). Nocturia (nocturnal frequency) is a common LUTD in patients with PD, and which not only impairs quality of life but also disturbs sleep and results in falling and fracture. In general, nocturnal polyuria and decrease in bladder volume are considered to be common causes of nocturia. We previously reported that not only decreased bladder capacity but also nocturnal polyuria may have a greater role in the causes of nocturia in patients with PD, and the pathophysiology of nocturnal polyuria in PD may be associated with abnormal circadian rhythm of AVP. However, the other pathophysiology of nocturnal polyuria in PD has not been known. Recently, the association between melatonin secretion and nocturia in elderly individuals is reported.
Methods: Eighteen patients with PD with motor fluctuations were recruited; those with other conditions that might have influenced lower urinary tract function were excluded. All studied subjects were evaluated using a lower urinary tract symptom questionnaire and bladder diary (voiding frequency diary), and blood serum of them were collected every 4 hours for 24 hours to evaluate the circadian levels of melatonin.
Results: Fourteen patients with PD (77.8%) had nocturnal polyuria. Ten patients with PD (55.6%) had decreased amplitude/night-to-daytime ratio of melatonin secretion, eight (44.4%) had a phase advance of the nocturnal melatonin secretion, and seventeen (44.4%) had decreased duration/disruption of melatonin secretion. All patients with PD and nocturnal polyuria had one and more of abnormal melatonin secretion which described above.
Conclusions: In patients with PD, nocturnal polyuria and abnormal melatonin secretion were coexisted with high probability. Thus, the pathophysiology of nocturnal polyuria in patients with PD may be associated with abnormal circadian rhythm of melatonin.
To cite this abstract in AMA style:
T. Uchiyama, T. Yamamoto, K. Suzuki, T. Kadowaki, A. Numao, H. Fujita, Y. Watanabe, T. Matsubara, M. Miyamoto, K. Kaga, T. Yamanishi, R. Sakakibara, S. Kuwabara, K. Hirata. Abnormal melatonin secretion rhythm and nocturnal polyuria in patients with Parkinson’s disease [abstract]. Mov Disord. 2017; 32 (suppl 2). https://www.mdsabstracts.org/abstract/abnormal-melatonin-secretion-rhythm-and-nocturnal-polyuria-in-patients-with-parkinsons-disease/. Accessed June 14, 2025.« Back to 2017 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/abnormal-melatonin-secretion-rhythm-and-nocturnal-polyuria-in-patients-with-parkinsons-disease/