Session Information
Date: Thursday, June 23, 2016
Session Title: Dystonia
Session Time: 12:00pm-1:30pm
Location: Exhibit Hall located in Hall B, Level 2
Objective: To explore national differences in the use of abobotulinumtoxinA (ABO) in the management of cervical dystonia (CD).
Background: Botulinum toxin injections (including ABO) are indicated as first line treatment for CD in many countries. Patient surveys have suggested potential national differences in the way CD is managed. The MetaCD study includes data from 2 observational international studies (INTEREST IN CD1 and 2) and 1 US registry (ANCHOR-CD), which follow the course of BoNT-A treated CD in routine practice.
Methods: We present here descriptive statistics from the Baseline/first injection visit to describe the utilisation of ABO. Data are presented for the top 5 MetaCD enrolling countries (each with ≥4 active sites and data from ≥40 subjects).
Results: The top 5 ABO enrolling countries were the USA (n=277), France (n=118), Russia (n=96), Germany (n=95) and the UK (n=59). Table 1 presents injection practice parameters analysed per country. Although the median dose of ABO (500U) was similar in each country, the ranges indicated distinct differences in injection practice. It can be seen that the median number of injection placement sites in the UK and France were lower than in Russia, USA and Germany despite the median number of muscles injected being similar. Injectors in Germany and the USA were much more likely to use injection guidance (mainly electromyography) than those in Russia and the UK (72% and 60% vs. 13% and 2%, respectively). 
Conclusions: The range of these data highlight distinct differences in injection practice between countries. It is hypothesized that factors including: access to specialist treatment, injector training and service reimbursement (e.g. private or state funded) may all contribute to these differences. The large data set provided by MetaCD will allow assessment of the clinical relevance of these differences in future longitudinal analyses.
To cite this abstract in AMA style:
R. Trosch, V.P. Misra, P. Maisonobe, S. Om. AbobotulinumtoxinA for cervical dystonia: A meta-analysis of injection practices across 5 countries [abstract]. Mov Disord. 2016; 31 (suppl 2). https://www.mdsabstracts.org/abstract/abobotulinumtoxina-for-cervical-dystonia-a-meta-analysis-of-injection-practices-across-5-countries/. Accessed June 14, 2025.« Back to 2016 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/abobotulinumtoxina-for-cervical-dystonia-a-meta-analysis-of-injection-practices-across-5-countries/