Session Information
Date: Monday, September 23, 2019
Session Title: Functional (Psychogenic) Movement Disorders
Session Time: 1:45pm-3:15pm
Location: Les Muses Terrace, Level 3
Objective: In order to better understand the underlying mechanisms of functional movement disorders (FMD), we set out to explore changes in functional connectivity and intrinsic activity of the default mode network (DMN), salience network (SN) and frontoparietal networks (FPN) in patients with hyperkinetic FMD compared to healthy controls at rest.
Background: Currently, the pathophysiological basis of FMD remains poorly understood. Resting-state fMRI (rs-fMRI) is a powerful tool to better understand intrinsic and functional connectivity of neural networks in the absence of a specific task. Identifying aberrations in resting state networks (RSN) may provide crucial new insights into the mechanism of FMD.
Method: In this study, resting-state fMRI was performed in seventeen patients with FMD and seventeen age-, sex- and education matched healthy controls. A data driven approach, using independent component analysis (ICA), was used to investigate the following prespecified networks: the frontoparietal, salience and default mode network. We combined intra- and inter-network functional connectivity with power spectral density measures of time courses to examine functioning of RSN.
Results: Compared with healthy controls, patients with FMD had significantly decreased lower frequency oscillations, and significantly increased higher frequency oscillations in the precuneus (FDR-corrected p<0.05). No significant differences were found between groups regarding intra- or inter-network functional connectivity.
Conclusion: In conclusion, our results reveal alterations in intrinsic functioning of the precuneus network in patients with hyperkinetic FMD with no significant differences in functional connectivity between groups. Because the precuneus is associated with attention shifting and sense of agency, the aberrant intrinsic functioning found in this network support the hypothesis of mechanisms associated with an impaired sense of agency and attentional dysregulation in patients with FMD. The lack of differences in functional connectivity between groups might be explained by heterogeneity within the studied group or could be an indication of variation in the mechanism of FMD between patients.
To cite this abstract in AMA style:
R. Marapin, H. Horn, J. Gelauff, B. de Jong, Y. Dreissen, J. Koelman, R. Renken, J. Marsman, M. Tijssen. Altered intrinsic power spectral density of the precuneus in patients with hyperkinetic functional movement disorders [abstract]. Mov Disord. 2019; 34 (suppl 2). https://www.mdsabstracts.org/abstract/altered-intrinsic-power-spectral-density-of-the-precuneus-in-patients-with-hyperkinetic-functional-movement-disorders/. Accessed June 14, 2025.« Back to 2019 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/altered-intrinsic-power-spectral-density-of-the-precuneus-in-patients-with-hyperkinetic-functional-movement-disorders/