Session Information
Date: Wednesday, June 7, 2017
Session Title: Parkinson's Disease: Cognition
Session Time: 1:15pm-2:45pm
Location: Exhibit Hall C
Objective: To evaluate the factors and possible mechanisms associated with anosognosia for LIDs in patients with PD using movie presentations and mirrored self-images.
Background: Levodopa-induced dyskinesias (LIDs) are the most common side effects of long-term dopaminergic treatment in Parkinson’s disease1 (PD). Some studies have suggested that PD patients may be partially or even completely unaware (anosognosia) of the presence of LIDs2.
Methods: Thirty patients (15 with LIDs and 15 without LIDs) and 15 healthy volunteers (HVs) were enrolled. Patients were video-recorded and awareness of LIDs was evaluated through videos and mirrored self-images. Patients, caregivers and a mo-vement disorder specialist rated both instruments. Neurological assessment included the Unified Parkinson’s Disease Rating Scale, the Unified Dyskinesia Rating Scale, the Mini-Mental State Examination, the Montreal Cognitive Assessment, the Beck Depression Inventory, the Beck Anxiety Inventory, the Semantic and Phonologic Verbal Fluency Tests, the Digit Span Task, and the Clock Drawing Test.
Results: Two patients (13.3%) completely denied LIDs, while six patients (40%) significantly underestimated their dyskinesias. Video was superior to the mirror self-images to improve awareness of LIDs. Poor self-awareness did not correlate with cognitive tests and psychiatric scales.
Conclusions: Results confirm that anosognosia and poor self-awareness with the presence of LIDs are common. Therefore, the assessment of dyskinesia in PD patients needs a meticulous interview and, if possible, with the support of visual aids.
References: 1. Pietracupa S, Latorre A, Berardelli A, Fabbrini G. Parkinsonian Patients and Poor Awareness of Dyskinesias. Frontiers in Neurology. 2014;5:32. doi:10.3389/fneur.2014.00032.
2. Self-unawareness of levodopa induced dyskinesias in patients with Parkinson’s disease. Brain Cogn 2014 Oct 21;90:135-41. Epub 2014 Jul 21. Martina Amanzio, Sara Palermo, Maurizio Zibetti, Daniela Leotta, Rosalba Rosato, Giuliano Geminiani, Leonardo Lopiano
To cite this abstract in AMA style:
R. Doyle Maia, F. Cardoso, P. Caramelli. Anosognosia for Levododopa-induced Dyskinesias in PD – Frequency [abstract]. Mov Disord. 2017; 32 (suppl 2). https://www.mdsabstracts.org/abstract/anosognosia-for-levododopa-induced-dyskinesias-in-pd-frequency/. Accessed June 14, 2025.« Back to 2017 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/anosognosia-for-levododopa-induced-dyskinesias-in-pd-frequency/