Category: Epidemiology
Objective: We aimed to identify differences and analyze the potential added value of the updated Movement Disorders Society (MDS) research criteria for prodromal Parkinson’s disease (PD) versus the original criteria in identifying incident PD in an unselected elderly population.
Background: In 2015, a task force of the MDS proposed evidence-based, probabilistic research diagnostic criteria for prodromal PD. In 2019, a first update of the criteria was presented, which incorporated new evidence for risk and prodromal markers. It adapted likelihood ratios for markers already included and supplemented them with four new markers.
Method: We applied the MDS criteria to participants of the prospective population-based Bruneck Study of the 2005 assessment (n=574, aged 55–94 years) and identified cases of incident PD during 5-year and 10-year follow-up visits. Probabilities for prodromal PD using updated criteria were compared with those derived from original criteria within and across groups.
Results: While median baseline probabilities for prodromal PD decreased from 2.4% (25th– 75th percentile: 0.6–8.7%) using original criteria to 1.8% (0.4–8.1%; p<0.001) with updated criteria, 16 participants met the ≥80% probability threshold for probable prodromal PD using updated criteria as compared with 12 using original criteria. Updated probabilities in participants with incident PD were higher than the original ones at 87.2% (69.4–90.3%) versus 84.6% (57.8–88.5%; p=0.041) for the 5-year follow-up and 69.2% (21.3–90.2%) versus 62.0% (19.9–86.9%; p=0.096) for the 10-year follow-up. In participants who remained free of PD during follow-up, updated probabilities were lower than the original ones (p<0.001). In absolute numbers, only few participants with incident PD were reclassified and changes in measures of predictive accuracy were low.
Conclusion: The updated MDS criteria were superior to the original MDS criteria with regard to separating individuals with low and high probabilities indicating presence of prodromal PD, but improvements in predictive accuracy were low.
To cite this abstract in AMA style:
K. Marini, K. Seppi, L. Tschiderer, S. Kiechl, H. Stockner, P. Willeit, J. Willeit, A. Djamshidian, G. Rungger, W. Poewe, P. Mahlknecht. Application of the updated MDS criteria for prodromal Parkinson’s disease to a population-based 10-year study [abstract]. Mov Disord. 2021; 36 (suppl 1). https://www.mdsabstracts.org/abstract/application-of-the-updated-mds-criteria-for-prodromal-parkinsons-disease-to-a-population-based-10-year-study/. Accessed June 15, 2025.« Back to MDS Virtual Congress 2021
MDS Abstracts - https://www.mdsabstracts.org/abstract/application-of-the-updated-mds-criteria-for-prodromal-parkinsons-disease-to-a-population-based-10-year-study/